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Heat shock protein 70 (HSP70) inhibitor JG-345

Invented by Dr. Jason Gestwicki
Invented at University Of Michigan

Info

Catalogue Number 157978
Antigen/Gene or Protein Targets Heat shock protein 70 (HSP70)
Relevance The benzothiazole rhodacyanines, MKT-077 analogue, JG-345 was designed as a small molecule with greater stability and potency to inhibit members of the heat shock protein 70 (Hsp70) family of molecular chaperones. Inhibiting Hsp70 chaperones induce apoptosis in breast cancer cell lines. This inhibitor would be useful in the study of Hsp70 chaperones and oncology research.
Research Area Cancer

References

There are 7 reference entries for this reagent.

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References: 7 entries

Shao et al. 2020. Bioorg Med Chem Lett. 30(5):126954. PMID: 31952963.

Taguwa et al. 2019. Cell Rep. 26(4):906-920.e3. PMID: 30673613.

Rinaldi et al. 2018. ACS Chem Biol. 13(11):3142-3152. PMID: 30372610.

Shao et al. 2018. J Med Chem. 61(14):6163-6177. PMID: 29953808.

Young et al. 2016. Cell Chem Biol. 23(8):992-1001. PMID: 27499529.

Li et al. 2013. ACS Med Chem Lett. 4(11):. PMID: 24312699.

Rousaki et al. 2011. J Mol Biol. 411(3):614-32. PMID: 21708173.


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References: 7 entries

Shao et al. 2020. Bioorg Med Chem Lett. 30(5):126954. PMID: 31952963.

Taguwa et al. 2019. Cell Rep. 26(4):906-920.e3. PMID: 30673613.

Rinaldi et al. 2018. ACS Chem Biol. 13(11):3142-3152. PMID: 30372610.

Shao et al. 2018. J Med Chem. 61(14):6163-6177. PMID: 29953808.

Young et al. 2016. Cell Chem Biol. 23(8):992-1001. PMID: 27499529.

Li et al. 2013. ACS Med Chem Lett. 4(11):. PMID: 24312699.

Rousaki et al. 2011. J Mol Biol. 411(3):614-32. PMID: 21708173.


Add a reference

Inventor Information