Heat shock protein 70 (HSP70) inhibitor JG-231
Invented by Dr. Jason Gestwicki at University Of Michigan
Heat shock protein 70 (HSP70) inhibitor JG-98
Invented by Dr. Jason Gestwicki
Invented at University Of Michigan
- Datasheet
- References (7)
- Inventor Info
Info
| Catalogue Number | 157976 |
| Antigen/Gene or Protein Targets | Heat shock protein 70 (HSP70) |
| Relevance | The benzothiazole rhodacyanines, MKT-077 analogue, JG-98 was designed as a small molecule with greater stability and potency to inhibit members of the heat shock protein 70 (Hsp70) family of molecular chaperones. Inhibiting Hsp70 chaperones induce apoptosis in breast cancer cell lines and xenograft model. This inhibitor would be useful in the study of Hsp70 chaperones and oncology research. |
| Research Area | Cancer |
Heat shock protein 70 (HSP70) inhibitor JG-345
Invented by Dr. Jason Gestwicki at University Of Michigan
References: 7 entries
Shao et al. 2020. Bioorg Med Chem Lett. 30(5):126954. PMID: 31952963.
Taguwa et al. 2019. Cell Rep. 26(4):906-920.e3. PMID: 30673613.
Rinaldi et al. 2018. ACS Chem Biol. 13(11):3142-3152. PMID: 30372610.
Shao et al. 2018. J Med Chem. 61(14):6163-6177. PMID: 29953808.
Young et al. 2016. Cell Chem Biol. 23(8):992-1001. PMID: 27499529.
Li et al. 2013. ACS Med Chem Lett. 4(11):. PMID: 24312699.
Rousaki et al. 2011. J Mol Biol. 411(3):614-32. PMID: 21708173.
Add a reference
References: 7 entries
Shao et al. 2020. Bioorg Med Chem Lett. 30(5):126954. PMID: 31952963.
Taguwa et al. 2019. Cell Rep. 26(4):906-920.e3. PMID: 30673613.
Rinaldi et al. 2018. ACS Chem Biol. 13(11):3142-3152. PMID: 30372610.
Shao et al. 2018. J Med Chem. 61(14):6163-6177. PMID: 29953808.
Young et al. 2016. Cell Chem Biol. 23(8):992-1001. PMID: 27499529.
Li et al. 2013. ACS Med Chem Lett. 4(11):. PMID: 24312699.
Rousaki et al. 2011. J Mol Biol. 411(3):614-32. PMID: 21708173.
Add a reference
Inventor Information
Inventors
|
Dr. Jason Gestwicki |
