Cancer Research Technology
Log in Register
Menu

Anti-Golgin-97 [CDF4] monoclonal antibody
NEW

Invented by Martin Fritzler at University Of Calgary

Info

Catalogue Number 157877
Applications IF WB
Antigen/Gene or Protein Targets Golgin 97
Synonyms Golgin subfamily A member 1
Reactivity Human and Rabbit
Relevance The Golgi complex is an intricate cytoplasmic organelle that has a major function in the processing, transporting, and sorting of intracellular proteins following synthesis in the rough endoplasmic reticulum. Golgins are Golgi-localized proteins with extensive coiled-coil structure throughout the entire polypeptide which serve as tethering molecules or matrix proteins for the cisternal architecture of Golgi apparatus. Glogins belonging to the Glutamate receptor-interacting protein (GRIP) family are targeted to the trans-face of the Golgi by their C-terminal GRIP domains and play an essential role as tethering molecules for tubulovesicular carriers of the trans-Golgi Network (TGN).

Golgin-97 resides on the cytoplasmic face of the Golgi and plays an essential role as tethering molecules on the TGN for retrograde traffic from the early and/or recycling endosomes. As a GRIP family member, Golgin-97 maintains cell polarity. Binding to the Golgi membrane is mediated by the G protein family member Arl1, and this pathway is a key regulatory process for endosome–TGN traffic.
Host Mouse
Positive Control IgG1
Molecular Weight (kDa) 88
Notes Golgin-97 is a peripheral membrane protein with a unique localization on the cytoplasmic face of the Golgi apparatus, which makes it a useful marker for immunodetection and identification of the Golgi apparatus in cells.
Research Area Cell Type or Organelle Marker

References

There are 1 reference entries for this reagent.

View All References

References: 1 entry

Nozawa et al. 2009. Cell Biol Int. 33(2):148-57. PMID: 19000931.


Add a reference

References: 1 entry

Nozawa et al. 2009. Cell Biol Int. 33(2):148-57. PMID: 19000931.


Add a reference

Inventor Information