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- Inventor Info
|Antigen/Gene or Protein Targets||Golgin 97|
|Synonyms||Golgin subfamily A member 1|
|Reactivity||Human and Rabbit|
The Golgi complex is an intricate cytoplasmic organelle that has a major function in the processing, transporting, and sorting of intracellular proteins following synthesis in the rough endoplasmic reticulum. Golgins are Golgi-localized proteins with extensive coiled-coil structure throughout the entire polypeptide which serve as tethering molecules or matrix proteins for the cisternal architecture of Golgi apparatus. Glogins belonging to the Glutamate receptor-interacting protein (GRIP) family are targeted to the trans-face of the Golgi by their C-terminal GRIP domains and play an essential role as tethering molecules for tubulovesicular carriers of the trans-Golgi Network (TGN).
Golgin-97 resides on the cytoplasmic face of the Golgi and plays an essential role as tethering molecules on the TGN for retrograde traffic from the early and/or recycling endosomes. As a GRIP family member, Golgin-97 maintains cell polarity. Binding to the Golgi membrane is mediated by the G protein family member Arl1, and this pathway is a key regulatory process for endosome–TGN traffic.
|Molecular Weight (kDa)||88|
|Notes||Golgin-97 is a peripheral membrane protein with a unique localization on the cytoplasmic face of the Golgi apparatus, which makes it a useful marker for immunodetection and identification of the Golgi apparatus in cells.|
|Research Area||Cell Type or Organelle Marker|
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