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Sox10iCre/+; Myrffl/fl mouse
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Info

Catalogue Number 157783
Antigen/Gene or Protein Targets Myrf (myelin regulatory factor)
Disease Keywords tamoxifen activated inactivation of Myrf for demyelination of throughout the CNS.
Model Conditional KO
Relevance Deymelination restricted to CNS & lack of remyelination.
Breeding Information Sox10iCre/+;MyrfFl/Fl mouse line can be bred with Sox10+/+;MyrfFl/Fl mice where 50% offspring will be Sox10iCre/+.
Conditional Yes
Conditional Description inducible demyelination without remyelination
Growth/Phenotype Keywords Demyelination of CNS
Strain C57BL/6
Mouse Genetic Background/Cross History MyrfFl/Fl mouse line crossed with a Sox10-CreERT transgenic line expressing tomoxifen inducible Cre recombinase in the oligodendrocyte lineage.
Research Area Neurobiology

References

There are 3 reference entries for this reagent.

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References: 3 entries

30996143 19596243

McKenzie et al. 2014. Science. 346(6207):318-22. PMID: 25324381.

Koenning et al. 2012. J Neurosci. 32(36):12528-42. PMID: 22956843.


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References: 3 entries

30996143 19596243

McKenzie et al. 2014. Science. 346(6207):318-22. PMID: 25324381.

Koenning et al. 2012. J Neurosci. 32(36):12528-42. PMID: 22956843.


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