Cat. #157783
Sox10iCre/+; Myrffl/fl mouse
Cat. #: 157783
Sub-type: Mouse
Availability: 6-8 weeks
Disease: Tamoxifen activated inactivation of Myrf for demyelination of throughout the CNS
Model: Conditional KO
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Contributor
Inventor: Ben Emery
Institute: Oregon Health & Science University
Tool Details
*FOR RESEARCH USE ONLY
- Tool name: Sox10iCre/+; Myrffl/fl mouse
- Tool sub type: Mouse
- Disease: Tamoxifen activated inactivation of Myrf for demyelination of throughout the CNS
- Model: Conditional KO
- Conditional: Yes
- Conditional description: inducible demyelination without remyelination
- Description: Deymelination restricted to CNS & lack of remyelination.
- Genetic background: MyrfFl/Fl mouse line crossed with a Sox10-CreERT transgenic line expressing tomoxifen inducible Cre recombinase in the oligodendrocyte lineage.
- Phenotype: Demyelination of CNS
- Strain: C57BL/6
- Breeding information: Sox10iCre/+;MyrfFl/Fl mouse line can be bred with Sox10+/+;MyrfFl/Fl mice where 50% offspring will be Sox10iCre/+.
Handling
- Shipping conditions: Embryo/Spermatoza- Dry Ice
Target Details
- Target: Myrf (myelin regulatory factor)
References
- 30996143 19596243
- McKenzie et al. 2014. Science. 346(6207):318-22. PMID: 25324381.
- Koenning et al. 2012. J Neurosci. 32(36):12528-42. PMID: 22956843.
