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Anti-OC [Fab-12] recombinant antibody

Invented by Kaisa Ivaska-Papaioannou , Urpo Lamminmäki
Invented at University Of Turku

Info

Catalogue Number 157726
Applications ELISA
Antigen/Gene or Protein Targets osteocalcin - any carboxylation status
Synonyms bone gamma-carboxyglutamic acid-containing protein, BGLAP, OC
Reactivity Human
Relevance Osteocalcin, also known as bone gamma-carboxyglutamic acid-containing protein (BGLAP), is a small (49-amino-acid) noncollagenous protein hormone found in bone and dentin. Osteocalcin is a bone-specific protein which contains three glutamic acid residues (Glu) that undergo post-translational gamma-carboxylation. Osteocalcin is secreted solely by osteoblasts and thought to play a role in the body's metabolic regulation. In its carboxylated form it binds calcium directly and thus concentrates in bone. In its uncarboxylated form, osteocalcin acts as a hormone in the body, signalling in the pancreas, fat, muscle, testes, and brain.
Osteocalcin can be used as a biochemical marker for acute stress response and bone formation.
Host Human
Notes Recombinant antibody binding osteocalcin with any carboxylation status. Binding site was concluded to be N-terminal and within Trp5-Arg20.
Research Area Developmental Biology, Metabolism, Reproductive Biology

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Inventor Information

Inventors

Kaisa Ivaska-Papaioannou

Kaisa Ivaska-Papaioannou

Urpo Lamminmäki

Urpo Lamminmäki

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