Anti-uncarboxylated osteocalcin (ucOC) [Fab-19] recombinant antibody
Invented by Kaisa Ivaska-Papaioannou at University Of Turku
|Antigen/Gene or Protein Targets||osteocalcin - any carboxylation status|
|Synonyms||bone gamma-carboxyglutamic acid-containing protein, BGLAP, OC|
Osteocalcin, also known as bone gamma-carboxyglutamic acid-containing protein (BGLAP), is a small (49-amino-acid) noncollagenous protein hormone found in bone and dentin. Osteocalcin is a bone-specific protein which contains three glutamic acid residues (Glu) that undergo post-translational gamma-carboxylation. Osteocalcin is secreted solely by osteoblasts and thought to play a role in the body's metabolic regulation. In its carboxylated form it binds calcium directly and thus concentrates in bone. In its uncarboxylated form, osteocalcin acts as a hormone in the body, signalling in the pancreas, fat, muscle, testes, and brain.
Osteocalcin can be used as a biochemical marker for acute stress response and bone formation.
|Notes||Recombinant antibody binding osteocalcin with any carboxylation status. Binding site was concluded to be N-terminal and within Trp5-Arg20.|
|Research Area||Developmental Biology, Metabolism, Reproductive Biology|
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