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Monoclonal Antibodies

Anti-OC [Fab-12] recombinant antibody

Invented by Kaisa Ivaska-Papaioannou , Urpo Lamminmäki
Invented at University Of Turku
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Taken from Supplemental Figure 1 in Arponen et al Calcified Tissue International volume 107, pages 529–542(2020). Antibody binding site was determined for C-A12 (A). Linearity of dilution was determined by adding 20 ng/ml ucOC peptide in buffer (square), serum (cross) or plasma (plus) samples and performing serial dilutions (B) Also, regression of dilution was determined and immunoreactivity was lost when comparing serum and plasma samples to buffer (C). The effect of sample handling was assessed with serum (D) and plasma (E) samples at RT (black) +4℃ (white) and -20℃ (gray). C-A12 based immunoassay was compared with a validated tOC assay, 2H9/6F9, (F) and Spearman’s correlation is shown.
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Catalogue Number 157726
Applications ELISA
Antigen/Gene or Protein Targets osteocalcin - any carboxylation status
Synonyms bone gamma-carboxyglutamic acid-containing protein, BGLAP, OC
Reactivity Human
Relevance Osteocalcin, also known as bone gamma-carboxyglutamic acid-containing protein (BGLAP), is a small (49-amino-acid) noncollagenous protein hormone found in bone and dentin. Osteocalcin is a bone-specific protein which contains three glutamic acid residues (Glu) that undergo post-translational gamma-carboxylation. Osteocalcin is secreted solely by osteoblasts and thought to play a role in the body's metabolic regulation. In its carboxylated form it binds calcium directly and thus concentrates in bone. In its uncarboxylated form, osteocalcin acts as a hormone in the body, signalling in the pancreas, fat, muscle, testes, and brain.
Osteocalcin can be used as a biochemical marker for acute stress response and bone formation.
Host Human
Notes Recombinant antibody binding osteocalcin with any carboxylation status. Binding site was concluded to be N-terminal and within Trp5-Arg20.
Research Area Developmental Biology, Metabolism, Reproductive Biology

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Inventor Information

Inventors

Kaisa Ivaska-Papaioannou

Kaisa Ivaska-Papaioannou

Urpo Lamminmäki

Urpo Lamminmäki

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Invented at

University Of Turku
University Of Turku

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