Anti-Estradiol immuno complex [C6] recombinant antibody
Invented by Urpo Lamminmäki
Invented at University Of Turku
- References (1)
- Inventor Info
|Applications||ELISA IF IP|
|Antigen/Gene or Protein Targets||estradiol immunocomplex|
Estradiol is an oestrogen steroid hormone and the major female sex hormone. It is involved in the regulation of the estrous and menstrual female reproductive cycles. With age and in the case of pathologies such as ovarian failure and following surgical removal of the oavries, levels of estradiol can fall. This results in symptoms such as osteoporosis, vaginal changes, changes to the skin and hot flushes.
Recombinant anti-estradiol immunocomplex antibody, clone [C6], binds to the immunocomplex of the anti- Estradiol-17-beta antibody clone [S16] and Estradiol-17-beta. For use in the detection of estradiol in low levels.
|Molecular Weight (kDa)||144535.08|
The use of this antibody alongside the anti-estradiol-17-beta antibody makes up the basis for an estradiol assay which addresses the very low circulatory levels of estradiol on blood samples which causes many similar competitive immunoassays to fail. Here the immunocomplex antibody is used to detect the levels of estradiol bound to anti-estradiol-17-beta, increasing the sensitivity of measurements.
Estradiol is implicated in both physiology, pathophysiology and developmental biology making this antibody pair, and the assay they facilitate, a useful tool in a number of research areas as well as for diagnostic purposes.
Please note, if this reagent will be used in a non-competitive immunoassay then you may require a license to the following patent rights which are held by VTT Technical Research Centre of Finland (US7749712B2; EP1579222B1, EP1579222B8, BRPI0316384B1, CN1711476B, JP4729701B2, NO338417B1, ZA200503475B).
|Research Area||Developmental Biology, Reproductive Biology|
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