Anti-GTP [2A4] recombinant antibody
Invented by Urpo Lamminmäki at University Of Turku
|Antigen/Gene or Protein Targets||GTP|
|Relevance||GTPases are central cellular signaling proteins, which cycle between a GDP-bound inactive and a GTP-bound active conformation in a controlled manner. Ras GTPases are frequently mutated in cancer and so far only few experimental inhibitors exist. The most common methods for monitoring GTP hydrolysis rely on luminescent GDP- or GTP-analogs. (From Kopra et al Anal. Chem. 2015, 87, 6, 3527–3534)|
|Notes||An affinity matured variant of anti-GTP [2A4] which can also be found on the Ximbio website.|
|Research Area||Cancer, Metabolism|
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