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Catalogue Number
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157664 |
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Amino Acid Sequence
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PPRRGLIKLKTSSNTKENSVVASLRP
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Cellular/Tissue Localisation
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Binds to extracellular matrix proteins present in malignant tissues
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Synonyms
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PL5, Bi-specific tenascin-C and fibronectin targeted peptide
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Relevance
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Oncofetal fibronectin (FN-EDB) and tenascin-C C domain (TNC-C) are not present in the extracellular matrix of adult tissues but they are up-regulated in tumours and malignant tissues. Both have been used as targets for antibody-based therapies. This bi-specific peptide has enhanced affinity to bind to these receptor proteins so PL5 may be useful as an affinity ligand for delivery of diagnostic compound into solid tumours.
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Antigen/Gene or Protein Targets
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Oncofetal fibronectin (FN-EDB) and tenascin-C C domain (TNC-C)
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Research Area
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Cancer, Extracellular Matrix
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