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PL5 Peptide
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Invented by Prakash Lingasamy, at University of Tartu Tambet Teesalu at University of Tartu

Info

Catalogue Number 157664
Amino Acid Sequence PPRRGLIKLKTSSNTKENSVVASLRP
Cellular/Tissue Localisation Binds to extracellular matrix proteins present in malignant tissues
Synonyms PL5, Bi-specific tenascin-C and fibronectin targeted peptide
Relevance Oncofetal fibronectin (FN-EDB) and tenascin-C C domain (TNC-C) are not present in the extracellular matrix of adult tissues but they are up-regulated in tumours and malignant tissues. Both have been used as targets for antibody-based therapies. This bi-specific peptide has enhanced affinity to bind to these receptor proteins so PL5 may be useful as an affinity ligand for delivery of diagnostic compound into solid tumours.
Antigen/Gene or Protein Targets Oncofetal fibronectin (FN-EDB) and tenascin-C C domain (TNC-C)
Research Area Cancer, Extracellular Matrix

References

There are 1 reference entries for this reagent.

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References: 1 entry

Lingasamy et al. 2019. Biomaterials. 219:119373. PMID: 31374479.


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References: 1 entry

Lingasamy et al. 2019. Biomaterials. 219:119373. PMID: 31374479.


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Inventor Information

Inventors

Prakash Lingasamy

Prakash Lingasamy

Tambet Teesalu

Tambet Teesalu

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