Cat. #157664
PL5 Peptide
Cat. #: 157664
Sub-type: Synthetic Peptide
Availability: Please enquire for quantities and pricing
Target: Oncofetal fibronectin (FN-EDB) and tenascin-C C domain (TNC-C)
Function: Marker
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Inventor: Prakash Lingasamy ; Tambet Teesalu
Institute: University of Tartu
Tool Details
*FOR RESEARCH USE ONLY
- Tool name: PL5 Peptide
- Alternate name: PL5, Bi-specific tenascin-C and fibronectin targeted peptide
- Tool sub type: Synthetic Peptide
- Sequence: PPRRGLIKLKTSSNTKENSVVASLRP
- Cellular tissue localisation: Binds to extracellular matrix proteins present in malignant tissues
- Target: Oncofetal fibronectin (FN-EDB) and tenascin-C C domain (TNC-C)
- Description: Oncofetal fibronectin (FN-EDB) and tenascin-C C domain (TNC-C) are not present in the extracellular matrix of adult tissues but they are up-regulated in tumours and malignant tissues. Both have been used as targets for antibody-based therapies. This bi-specific peptide has enhanced affinity to bind to these receptor proteins so PL5 may be useful as an affinity ligand for delivery of diagnostic compound into solid tumours.
- Function: Marker
- Expression system: Synthetic
Handling
- Shipping conditions: Dry Ice
Target Details
- Target: Oncofetal fibronectin (FN-EDB) and tenascin-C C domain (TNC-C)
References
- Lingasamy et al. 2019. Biomaterials. 219:119373. PMID: 31374479.
