Anti-pS114-BRCA1 [3C10G8] monoclonal antibody
Invented by Jo Morris , Ruth Densham
Invented at University Of Birmingham
- Datasheet
- References (1)
- Inventor Info
Info
| Catalogue Number | 156496 |
| Applications | IF IP WB |
| Antigen/Gene or Protein Targets | pS114-BRCA1 |
| Synonyms | pS114, BRCA1 |
| Reactivity | N/A |
| Relevance | BRCA1 proteins protect stalled replication forks from degradation by nucleases, through pathways that involve RAD51. Specifically, BRCA1 in complex with BARD1, and not the canonical BRCA1–PALB2 interaction, is required for fork protection. BRCA1–BARD1 is regulated by a conformational change mediated by the phosphorylation-directed prolyl isomerase PIN1. PIN1 activity enhances BRCA1–BARD1 interaction with RAD51, thereby increasing the presence of RAD51 at stalled replication structures. |
| Host | Mouse |
| Notes | Custom mouse monoclonal (3C10G8) antibody raised against BRCA1(pS114) using the following peptide: CFAKKENNpSPEHLKD (in which p indicates a phosphorylated residue). |
| Research Area | Cancer |
References: 1 entry
References: 1 entry
Inventor Information
Inventors
|
Jo Morris |
|
|
Ruth Densham |
