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PKCα cell line
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Catalogue Number 156372
Antigen/Gene or Protein Targets PKCα
Parental Line MCF-7
Synonyms MCF7
Host Human
Tissue Breast
Disease Keywords Breast Cancer; Tamoxifen Resistance
Model Cancer Model
Relevance Approximately 70% of breast cancer patients have estrogen receptor positive (ER+) tumors. The selective estrogen receptor modulator (SERM), tamoxifen, and aromatase inhibitors (AIs) represent first-line treatment for ER+ patients however, up to 50% of patients either do not respond or acquire resistance within 5 years of treatment. The MCF7-PKCa cell line was engineered to exogenously overexpress Protein Kinase C alpha (PKCα) which rendered it resistant to tamoxifen. MCF7-PKCα represents a valuable model for tamoxifen resistance and for screening the effectiveness of alternatives.
Research Area Cancer, Drug Discovery & Development
Notes Engineered to over-express PKCα.

References

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References: 1 entry

Xiong et al. 2017. J Med Chem. 60(4):1325-1342. PMID: 28117994.


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References: 1 entry

Xiong et al. 2017. J Med Chem. 60(4):1325-1342. PMID: 28117994.


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