#156372

PKCa cell line

Cat. #156372

PKCa cell line

Cat. #: 156372

Sub-type: Continuous

Unit size: 1x10^6 cells / vial

Availability: 10-12 weeks

Organism: Human

Tissue: Breast

Disease: Cancer

Model: Cancer Model

£575.00

This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.

Contributor

Inventor: Debra Tonetti

Institute: University of Illinois Chicago

Tool Details
Target Details
Applications
Handling
References

Tool Details

*FOR RESEARCH USE ONLY

  • Name: PKCa cell line
  • Alternate name: MCF7
  • Tool sub type: Continuous
  • Parental cell: MCF-7
  • Organism: Human
  • Tissue: Breast
  • Disease: Cancer
  • Model: Cancer Model
  • Description: Approximately 70% of breast cancer patients have estrogen receptor positive (ER+) tumors. The selective estrogen receptor modulator (SERM), tamoxifen, and aromatase inhibitors (AIs) represent first-line treatment for ER+ patients however, up to 50% of patients either do not respond or acquire resistance within 5 years of treatment. The MCF7-PKCa cell line was engineered to exogenously overexpress Protein Kinase C alpha (PKCa) which rendered it resistant to tamoxifen. MCF7-PKCa represents a va...
  • Additional notes: Engineered to over-express PKCa.

Target Details

  • Target: PKCÎ?„Â…

Applications

  • Application notes: Engineered to over-express PKCÎ?„Â….

Handling

  • Format: Frozen
  • Unit size: 1x10^6 cells / vial
  • Shipping conditions: Dry ice

References

  • Xiong et al. 2017. J Med Chem. 60(4):1325-1342. PMID: 28117994.