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Anti-Spectrin [RG/26] recombinant antibody

Invented at University of Oxford

Info

Catalogue Number 154838
Antigen/Gene or Protein Targets Spectrin
Reactivity Human
Relevance Spectrin is a cytoskeletal protein that lines the intracellular side of the plasma membrane of many cell types in pentagonal or hexagonal arrangements, forming a scaffolding and playing an important role in maintenance of plasma membrane integrity and cytoskeletal structure. In certain types of brain injury such as diffuse axonal injury, spectrin is irreversibly cleaved by the proteolytic enzyme calpain, destroying the cytosketelon. Spectrin cleavage causes the membrane to form blebs and ultimately to be degraded, usually leading to cell death.
Host Mouse
Immunogen Red cell membranes
Subclass IgG2a
Research Area Cardiovascular, Neurobiology, Protein Degradation

References

There are 4 reference entries for this reagent.

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References: 4 entries

Host vascular endothelial growth factor is trophic for Plasmodium falciparum-infected red blood cells.

Impact of constant storage temperatures and multiple warming cycles on the quality of stored red blood cells.

Sachanonta et al. 2008. Asian Pac J Allergy Immunol. 26(1):37-45. PMID: 18595528.

Wagner et al. 2014. Vox Sang. 106(1):45-54. PMID: 23909508.


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References: 4 entries

Host vascular endothelial growth factor is trophic for Plasmodium falciparum-infected red blood cells.

Impact of constant storage temperatures and multiple warming cycles on the quality of stored red blood cells.

Sachanonta et al. 2008. Asian Pac J Allergy Immunol. 26(1):37-45. PMID: 18595528.

Wagner et al. 2014. Vox Sang. 106(1):45-54. PMID: 23909508.


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