Anti-DMC1 [2H12/4] recombinant antibody
Invented at Cancer Research UK London Research Institute: Clare Hall Laboratories
- Datasheet
- References (6)
- Inventor Info
Info
| Catalogue Number | 154821 |
| Antigen/Gene or Protein Targets | DMC1 |
| Synonyms | Disrupted meiotic cDNA 1 homolog, Disrupted meiotic cDNA 1, yeast homolog of, dJ199H16.1, DMC 1, DMC1, DMC1 dosage suppressor of mck1 homolog, DMC1 dosage suppressor of mck1 homolog meiosis specific homologous recombination (yeast), DMC1 homologue |
| Reactivity | Bovine, Human and Mouse |
| Relevance | DMC1 is a meiosis-specific homologue of RecA/RAD51 and is an essential component of the meiotic recombination machinery in yeast and higher eukaryotes. |
| Host | Mouse |
| Immunogen | human DMC1 protein (expressed as 6xHis fusion in E. coli and band cut out of gel of insoluble pelet) |
| Subclass | IgG2a |
| Research Area | DNA Damage and Repair, Epigenetics & Nuclear Signalling |
| Notes |
Unstable after acidic elution. Does not cross react with hRad51. |
References: 6 entries
Erenpreisa et al. 2009. Exp Cell Res. 315(15):2593-603. PMID: 19463812.
Ikbkap/Elp1 deficiency causes male infertility by disrupting meiotic progression.
Lin et al. 2013. PLoS Genet. 9(5):e1003516. PMID: 23717213.
Masson et al. 1999. EMBO J. 18(22):6552-60. PMID: 10562567.
The meiosis-specific recombinase hDmc1 forms ring structures and interacts with hRad51.
The role of meiotic cohesin REC8 in chromosome segregation in gamma irradiation-induced endopolyploid tumour cells.
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References: 6 entries
Erenpreisa et al. 2009. Exp Cell Res. 315(15):2593-603. PMID: 19463812.
Ikbkap/Elp1 deficiency causes male infertility by disrupting meiotic progression.
Lin et al. 2013. PLoS Genet. 9(5):e1003516. PMID: 23717213.
Masson et al. 1999. EMBO J. 18(22):6552-60. PMID: 10562567.
The meiosis-specific recombinase hDmc1 forms ring structures and interacts with hRad51.
The role of meiotic cohesin REC8 in chromosome segregation in gamma irradiation-induced endopolyploid tumour cells.
Add a reference
