Anti-CD27 [LG8A6] monoclonal Antibody
Invented at Netherlands Cancer Institute
- Datasheet
- References (3)
- Inventor Info
Info
| Catalogue Number | 154800 |
| Applications | ELISA FACS IHC IP |
| Antigen/Gene or Protein Targets | CD27 |
| Synonyms | Tumor Necrosis Factor Receptor Superfamily, Member 7; TNFRSF7 |
| Reactivity | Human and Mouse |
| Relevance | CD27 is a member of the TNF-receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-κB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signalling process of this receptor. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor. |
| Host | Hamster |
| Immunogen | Armenian hamster fibroblasts transfected with the mouse CD27 DNA. |
| Subclass | IgG |
| Molecular Weight (kDa) | 60 |
| Myeloma Used | Sp2/0-Ag14 |
| Recommended Growing Conditions | IMDM + 1% ZAP, 37⁰C 5% CO2 |
| Strain | Armenian |
| Notes | Fusion partners: SP2/0 x spleen cells Armenian hamster |
| Research Area | Apoptosis and Programmed Cell Death, Cell Signaling & Signal Transduction, Immunology |
References: 3 entries
Hendriks et al. 2000. Nat Immunol. 1(5):433-40. PMID: 11062504.
Gravestein et al. 1996. J Exp Med. 184(2):675-85. PMID: 8760821.
Gravestein et al. 1995. Int Immunol. 7(4):551-7. PMID: 7547681.
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References: 3 entries
Hendriks et al. 2000. Nat Immunol. 1(5):433-40. PMID: 11062504.
Gravestein et al. 1996. J Exp Med. 184(2):675-85. PMID: 8760821.
Gravestein et al. 1995. Int Immunol. 7(4):551-7. PMID: 7547681.
Add a reference
