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Anti-CD27 [LG8A6] monoclonal Antibody
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Info

Catalogue Number 154800
Applications ELISA FACS IHC IP
Antigen/Gene or Protein Targets CD27
Synonyms Tumor Necrosis Factor Receptor Superfamily, Member 7; TNFRSF7
Reactivity Human and Mouse
Relevance CD27 is a member of the TNF-receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-κB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signalling process of this receptor. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor.
Host Hamster
Immunogen Armenian hamster fibroblasts transfected with the mouse CD27 DNA.
Subclass IgG
Molecular Weight (kDa) 60
Myeloma Used Sp2/0-Ag14
Recommended Growing Conditions IMDM + 1% ZAP, 37⁰C 5% CO2
Strain Armenian
Notes Fusion partners: SP2/0 x spleen cells Armenian hamster
Research Area Apoptosis and Programmed Cell Death, Cell Signaling & Signal Transduction, Immunology

References

There are 3 reference entries for this reagent.

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References: 3 entries

Hendriks et al. 2000. Nat Immunol. 1(5):433-40. PMID: 11062504.

Gravestein et al. 1996. J Exp Med. 184(2):675-85. PMID: 8760821.

Gravestein et al. 1995. Int Immunol. 7(4):551-7. PMID: 7547681.


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References: 3 entries

Hendriks et al. 2000. Nat Immunol. 1(5):433-40. PMID: 11062504.

Gravestein et al. 1996. J Exp Med. 184(2):675-85. PMID: 8760821.

Gravestein et al. 1995. Int Immunol. 7(4):551-7. PMID: 7547681.


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