Cat. #154800
Anti-CD27 [LG8A6]
Cat. #: 154800
Sub-type: Primary antibody
Unit size: 100 ug
Availability: 3-4 weeks
Target: CD27
Class: Monoclonal
Application: ELISA ; FACS ; IHC ; IP
Reactivity: Human ; Mouse
Host: Hamster
£300.00
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Institute: Netherlands Cancer Institute
Tool Details
*FOR RESEARCH USE ONLY
- Name: Anti-CD27 [LG8A6]
- Alternate name: Tumor Necrosis Factor Receptor Superfamily, Member 7; TNFRSF7
- Tool sub type: Primary antibody
- Class: Monoclonal
- Conjugation: Unconjugated
- Molecular weight: 60 kDa
- Strain: Armenian
- Reactivity: Human ; Mouse
- Host: Hamster
- Application: ELISA ; FACS ; IHC ; IP
- Description: CD27 is a member of the TNF-receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-ÄÂ?B and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signalling process of this receptor. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor.
- Immunogen: Armenian hamster fibroblasts transfected with the mouse CD27 DNA.
- Isotype: IgG
- Myeloma used: Sp2/0-Ag14
Target Details
- Target: CD27
- Molecular weight: 60 kDa
- Target background: CD27 is a member of the TNF-receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-
Applications
- Application: ELISA ; FACS ; IHC ; IP
Handling
- Format: Liquid
- Concentration: 0.9-1.1 mg/ml
- Unit size: 100 ug
- Storage buffer: PBS with 0.02% azide
- Storage conditions: -15° C to -25° C
- Shipping conditions: Shipping at 4° C
References
- Hendriks et al. 2000. Nat Immunol. 1(5):433-40. PMID: 11062504.
- Gravestein et al. 1996. J Exp Med. 184(2):675-85. PMID: 8760821.
- Gravestein et al. 1995. Int Immunol. 7(4):551-7. PMID: 7547681.
