Anti-DGKα [M8] monoclonal Antibody
Invented at Netherlands Cancer Institute
- Datasheet
- References (2)
- Inventor Info
Info
| Catalogue Number | 154780 |
| Applications | IP WB |
| Antigen/Gene or Protein Targets | DGKα |
| Synonyms | DGKA; Diacylglycerol Kinase Alpha |
| Reactivity | Human |
| Relevance | Diacylglycerol kinase alpha is an enzyme that belongs to the eukaryotic diacylglycerol kinase family. It acts as a modulator that competes with protein kinase C for the second messenger diacylglycerol in intracellular signalling pathways. It also plays an important role in the resynthesise of phosphatidylinositol's and phosphorylating diacylglycerol to phosphatidic acid. |
| Host | Mouse |
| Immunogen | Immunized with an Escherichia coli cell-expressed, affinity-purified glutathione S-transferase protein of a C-terminal portion (part of the Catalytic domain) of Rat DGKu. |
| Subclass | IgG1 |
| Molecular Weight (kDa) | 77 |
| Myeloma Used | Sp2/0-Ag14 |
| Recommended Growing Conditions | IMDM + 1% ZAP, 37 ⁰C 5% CO2 |
| Strain | Balb/c |
| Notes |
Fusion partners: Fusion of SP2/0 Mouse myeloma cells with spleen cells from a BALB/c Mouse. Against an Escherichia coli cell-expressed, affinity-purified glutathione S-transferase fusion protein of a C-terminal portion (part of the catalytic domain) of rat DGK. |
| Research Area | Cell Signaling & Signal Transduction, Immunology, Metabolism |
References: 2 entries
Cutrupi et al. 2000. EMBO J. 19(17):4614-22. PMID: 10970854.
Schaap et al. 1993. Biochem J. 289 ( Pt 3):875-81. PMID: 7679574.
Add a reference
References: 2 entries
Cutrupi et al. 2000. EMBO J. 19(17):4614-22. PMID: 10970854.
Schaap et al. 1993. Biochem J. 289 ( Pt 3):875-81. PMID: 7679574.
Add a reference
