Anti-CD11b/CR3 (Integrin Subunit Alpha M) [BEAR1] monoclonal antibody
Invented at Netherlands Cancer Institute
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- Inventor Info
Info
| Catalogue Number | 154771 |
| Applications | FACS IP |
| Antigen/Gene or Protein Targets | CD11b/CR3 |
| Synonyms | ITGAM; Leukocyte Adhesion Receptor MO1 |
| Reactivity | Human |
| Relevance |
ITGAM is one protein subunit that forms heterodimeric integrin alpha-M beta-2 (αMβ2) molecule, also known as macrophage-1 antigen (Mac-1) or complement receptor 3 (CR3). The second chain of αMβ2 is the common integrin β2 subunit known as CD18, and integrin αMβ2 thus belongs to the β2 subfamily (or leukocyte) integrins. αMβ2 is expressed on the surface of many leukocytes involved in the innate immune system, including monocytes, granulocytes, macrophages, and natural killer cells. It mediates inflammation by regulating leukocyte adhesion and migration and has been implicated in several immune processes such as phagocytosis, cell-mediated cytotoxicity, chemotaxis and cellular activation |
| Host | Mouse |
| Immunogen | The mouse was immunized with purified human monocytes |
| Subclass | IgG1 |
| Molecular Weight (kDa) | 160 |
| Myeloma Used | Sp2/0-Ag14 |
| Recommended Growing Conditions | IMDM + 1% ZAP, 37 ⁰C 5% CO2 |
| Strain | Balb/c |
| Notes | Fusion partners: SP2/0 x spleen cells origin BALB/C. |
| Research Area | Adhesion, Cell Signaling & Signal Transduction, Immunology |
