Anti-Keratin 14 [SPK14] monoclonal Antibody
Invented at Netherlands Cancer Institute
- Datasheet
- References (2)
- Inventor Info
Info
| Catalogue Number | 154748 |
| Applications | FACS IHC WB |
| Antigen/Gene or Protein Targets | Keratin14 |
| Synonyms | KRT14; Keratin 14 |
| Reactivity | Human, Pig and Feline |
| Relevance | Cytokeratin 14 is a member of the type I keratin family of intermediate filament proteins. Cytokeratin 14 is usually found as a heterodimer with type II keratin 5 and form the cytoskeleton of epithelial cells. Mutations in the genes for these keratins are associated with epidermolysis bullosa simplex and dermatopathia pigmentosa reticularis, both of which are autosomal dominant mutations |
| Host | Mouse |
| Immunogen | Mouse was immunized with a synthetic peptide corresponding to the carboxy-terminal sequence of human cytokeratin 14 (KVVSTHEQVLRTKN) coupled to keyhole limpet hemocyanin. |
| Subclass | IgG1 |
| Molecular Weight (kDa) | 51 |
| Myeloma Used | Sp2/0-Ag14 |
| Recommended Growing Conditions | IMDM + 1% ZAP, 37 ⁰C 5% CO2 |
| Strain | Balb/c |
| Notes | Fusion partners: SP2/0 x spleen cells origin BALB/C. Reacts exclusively with cytokeratin 14 which is present in basal cell compartments of stratified and combined epithelia. |
| Research Area | Cell Structure and Motility |
References: 2 entries
Ivanyi et al. 1993. Am J Vet Res. 54(7):1095-102. PMID: 7690208.
Ivanyi et al. 1992. Am J Vet Res. 53(3):304-14. PMID: 1375818.
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References: 2 entries
Ivanyi et al. 1993. Am J Vet Res. 54(7):1095-102. PMID: 7690208.
Ivanyi et al. 1992. Am J Vet Res. 53(3):304-14. PMID: 1375818.
Add a reference
