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Core 3- intestinal derived O-glycans and core 1- intestinal derived O-glycans double KO mouse

Info

Catalogue Number 154266
Antigen/Gene or Protein Targets Core 3- intestinal derived O-glycans and core 1- intestinal derived O-glycans
Disease Keywords Spontaneous Colitis-Associated Cancer, Colorectal Cancer, mucin, MUC2, Ulcerative Colitis, microbiome
Model Knock-Out
Relevance Defective intestinal mucin-type O-glycosylation causes colonic mucus barrier breach and subsequent microbiota-mediated activation of caspase1-dependent inflammasomes in colonic epithelial cells which cause spontaneous colitis-associated cancer in mice
Production Details Mice were generated by crossing core-3 intestinal derived O-glycans with core-1 intestinal derived O-glycans
Conditional No
Growth/Phenotype Keywords Spontaneous colitis-associated colon cancer
Strain C57BL/6
Mouse Genetic Background/Cross History Core-3 intestinal derived O-glycan mice (C57BL/6-129Sv1mJ mixed background) were crossed with Core-1 intestinal derived O-glycan mice (C57BL/6J, 129/SvImJ mixed, C57BL/6J congenic)
Zygosity unknown
Research Area Cancer, Cell Signaling & Signal Transduction, Genetic Studies Tools, Immunology, Other

References

There are 2 reference entries for this reagent.

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References: 2 entries

Bergstrom et al. 2016. Gastroenterology. 151(1):152-164.e11. PMID: 27059389.

Defective Intestinal Mucin-Type O-Glycosylation Causes Spontaneous Colitis-Associated Cancer in Mice.

Europe PMC ID: 27059389


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References: 2 entries

Bergstrom et al. 2016. Gastroenterology. 151(1):152-164.e11. PMID: 27059389.

Defective Intestinal Mucin-Type O-Glycosylation Causes Spontaneous Colitis-Associated Cancer in Mice.


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