Cat. #154266
Core 3- intestinal derived O-glycans and core 1- intestinal derived O-glycans double KO mouse
Cat. #: 154266
Sub-type: Mouse
Availability: 6-8 weeks
Disease: Spontaneous Colitis-Associated Cancer; Colorectal Cancer; Mucin; MUC2; Ulcerative Colitis; Microbiome
Model: Knock-Out
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Inventor: Lijun Xia
Institute: Oklahoma Medical Research Foundation
Tool Details
*FOR RESEARCH USE ONLY
- Tool name: Core 3- intestinal derived O-glycans and core 1- intestinal derived O-glycans double KO mouse
- Tool sub type: Mouse
- Disease: Spontaneous Colitis-Associated Cancer; Colorectal Cancer; Mucin; MUC2; Ulcerative Colitis; Microbiome
- Model: Knock-Out
- Conditional: No
- Description: Defective intestinal mucin-type O-glycosylation causes colonic mucus barrier breach and subsequent microbiota-mediated activation of caspase1-dependent inflammasomes in colonic epithelial cells which cause spontaneous colitis-associated cancer in mice
- Genetic background: Mice were generated by crossing core-3 intestinal derived O-glycans with core-1 intestinal derived O-glycans
- Phenotype: Spontaneous colitis-associated colon cancer
- Zygosity: unknown
- Strain: C57BL/6
- Production details: Mice were generated by crossing core-3 intestinal derived O-glycans with core-1 intestinal derived O-glycans
Handling
- Shipping conditions: Embryo/Spermatoza- Dry Ice
Target Details
- Target: Core 3- intestinal derived O-glycans and core 1- intestinal derived O-glycans
References
- Bergstrom et al. 2016. Gastroenterology. 151(1):152-164.e11. PMID: 27059389.
- Defective Intestinal Mucin-Type O-Glycosylation Causes Spontaneous Colitis-Associated Cancer in Mice.
