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2C4 cell line

Invented by George Stark, Ian Kerr

Info

Catalogue Number 154235
Parental Line HT 1080
Host Human
Disease Keywords Fibrosarcoma
Relevance The 2C4 cell line is a clonal derivative of the human fibrosarcoma cell line HT 1080. The 2C4 cell line clone expresses the simple cell-surface marker CD2 (normally expressed only on T cells) under the control of the 9-27 gene promoter. The 9-27 gene promoter is inducible by interferon gamma.
Research Area Cancer, Cell Signaling & Signal Transduction, Immunology
Recommended Growing Conditions DMEM + 10% heat-inactivated FBS + 400ug G418 per ml (As described by Kohlhuber et al., 1997)
Cellosaurus ID CVCL_1D50

References

There are 4 reference entries for this reagent.

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References: 4 entries

Kohlhuber et al. 1997. Mol Cell Biol. 17(2):695-706. PMID: 9001223.

A JAK1/JAK2 chimera can sustain alpha and gamma interferon responses.

Europe PMC ID: 9001223

Watling et al. 1993. Nature. 366(6451):166-70. PMID: 7901766.

Complementation by the protein tyrosine kinase JAK2 of a mutant cell line defective in the interferon-gamma signal transduction pathway.

Europe PMC ID: 7901766


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References: 4 entries

Kohlhuber et al. 1997. Mol Cell Biol. 17(2):695-706. PMID: 9001223.

A JAK1/JAK2 chimera can sustain alpha and gamma interferon responses.

Watling et al. 1993. Nature. 366(6451):166-70. PMID: 7901766.

Complementation by the protein tyrosine kinase JAK2 of a mutant cell line defective in the interferon-gamma signal transduction pathway.


Add a reference