Gamma2A Jak2 Cell Line
Invented by George Stark at Cancer Research UK London Research Institute: Lincoln's Inn Fields Cleveland Clinic Foundation
2C4 cell line
Invented by George Stark , Ian Kerr
Invented at Cancer Research UK London Research Institute: Lincoln's Inn Fields
- Datasheet
- References (4)
- Inventor Info
Info
| Catalogue Number | 154235 |
| Parental Line | HT 1080 |
| Host | Human |
| Disease Keywords | Fibrosarcoma |
| Relevance | The 2C4 cell line is a clonal derivative of the human fibrosarcoma cell line HT 1080. The 2C4 cell line clone expresses the simple cell-surface marker CD2 (normally expressed only on T cells) under the control of the 9-27 gene promoter. The 9-27 gene promoter is inducible by interferon gamma. |
| Research Area | Cancer, Cell Signaling & Signal Transduction, Immunology |
| Recommended Growing Conditions | DMEM + 10% heat-inactivated FBS + 400ug G418 per ml (As described by Kohlhuber et al., 1997) |
| Cellosaurus ID | CVCL_1D50 |
2C4-Gamma2A cell line
Invented by George Stark at Cancer Research UK London Research Institute: Lincoln's Inn Fields Cleveland Clinic Foundation
References: 4 entries
Kohlhuber et al. 1997. Mol Cell Biol. 17(2):695-706. PMID: 9001223.
A JAK1/JAK2 chimera can sustain alpha and gamma interferon responses.
Europe PMC ID: 9001223
Watling et al. 1993. Nature. 366(6451):166-70. PMID: 7901766.
Complementation by the protein tyrosine kinase JAK2 of a mutant cell line defective in the interferon-gamma signal transduction pathway.
Europe PMC ID: 7901766
Add a reference
References: 4 entries
Kohlhuber et al. 1997. Mol Cell Biol. 17(2):695-706. PMID: 9001223.
A JAK1/JAK2 chimera can sustain alpha and gamma interferon responses.
Watling et al. 1993. Nature. 366(6451):166-70. PMID: 7901766.
Complementation by the protein tyrosine kinase JAK2 of a mutant cell line defective in the interferon-gamma signal transduction pathway.
Add a reference
Inventor Information
Inventors
|
George Stark |
|
|
Ian Kerr |
