CHEC-7 immunomodulatory Peptide
Invented at Drexel University
- Datasheet
- References (3)
- Inventor Info
Info
| Catalogue Number | 154132 |
| Amino Acid Sequence | CHEASQC |
| Synonyms | Human neuroprotective polypeptide Diffusible Survival Evasion Peptide (DSEP) |
| Relevance | The CHEC-7 (peptide sequence CHEASQC) peptide is modified from immunomodulatory CHEC-9 peptide by eliminating two central alanines followed by cyclization to be a more potent uncompetitive sPLA2 inhibitor. The neuroprotective/anti-inflammatory cyclic heptapeptide, CHEC-7, stimulates HSP70's disaggregase activity and is used in the study of protein aggregate disease, including age-related failures of protein repair like Alzheimer’s Disease. The peptide also showed promising results in treating Autoimmune Myeloencephalitis tested in a rat model. |
| Research Area | Immunology, Neurobiology |
References: 3 entries
Cunningham et al. 2018. Rejuvenation Res. 21(6):527-534. PMID: 29651925.
Heptamer Peptide Disassembles Native Amyloid in Human Plasma Through Heat Shock Protein 70.
Europe PMC ID: 29651925
Uncompetitive Phospholipase A2 Inhibition by CHEC Sequences Including Oral Treatment of Experimental Autoimmune Myeloencephalitis
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References: 3 entries
Cunningham et al. 2018. Rejuvenation Res. 21(6):527-534. PMID: 29651925.
Heptamer Peptide Disassembles Native Amyloid in Human Plasma Through Heat Shock Protein 70.
Uncompetitive Phospholipase A2 Inhibition by CHEC Sequences Including Oral Treatment of Experimental Autoimmune Myeloencephalitis
Add a reference
