p53Lck-TLX1 Mouse
Invented at The Trustees of Columbia University in the City of New York
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- References (2)
- Inventor Info
Info
| Catalogue Number | 154093 |
| Antigen/Gene or Protein Targets | TLX1 |
| Disease Keywords | T cell acute lymphoblastic leukemia |
| Synonyms | T Cell Leukemia Homeobox 1, Homeo Box-11, Proto-Oncogene TCL-3, HOX11, TCL3 |
| Model | Transgenic |
| Relevance | TLX1 is an orphan homeobox gene. It was originally discovered in association with 4-7% of cases of T cell acute lymphoblastic leukaemia’s harbouring a t(10;14)(q24;q11) cytogenetic abnormality. Research showed the presence of the TLX1 gene on chromosome 10q24 juxtaposed with the T cell receptor (TCR) delta regulatory elements on chromosome 10, resulting in aberrant over-expression of the full and intact TLX1 gene. Juxtaposition with the TCR alpha locus was also seen. Elevated TLX1 expression in leukemic blasts is also detected in the absence of a translocation in ~50% (37/76) of paediatric T-ALL cases, as well as rare cases of B-AL. Clinically, TLX1+ T-ALLs are associated with a genetic signature associated with maturation arrest at an early cortical thymocyte stage of T cell development. This model organism recapitulates many molecular features of human leukaemia’s induced by the TLX family of TF oncogenes. |
| Production Details | The human TLX1 cDNA was amplified by PCR using BamHI restriction site containing primers and cDNA of the human T-cell leukemia cell line ALL-SIL as template and was cloned in the pUC1017 vector, downstream of the mouse T-cell specific p56Lck proximal promoter |
| Conditional | No |
| Strain | C57BL/6 |
| Mouse Genetic Background/Cross History | 129/Sv-C57Bl/6 mixed |
| Research Area | Cancer, Immunology |
| Notes | Transgenic mouse expressing human transcription factor Tlx1 in T cell progenitors under control of the LCK promoter |
References: 2 entries
De Keersmaecker et al. 2010. Nat Med. 16(11):1321-7. PMID: 20972433.
The TLX1 oncogene drives aneuploidy in T cell transformation.
Europe PMC ID: 20972433
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References: 2 entries
De Keersmaecker et al. 2010. Nat Med. 16(11):1321-7. PMID: 20972433.
The TLX1 oncogene drives aneuploidy in T cell transformation.
Add a reference
