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p53Lck-TLX1 Mouse

Info

Catalogue Number 154093
Antigen/Gene or Protein Targets TLX1
Disease Keywords T cell acute lymphoblastic leukemia
Synonyms T Cell Leukemia Homeobox 1, Homeo Box-11, Proto-Oncogene TCL-3, HOX11, TCL3
Model Transgenic
Relevance TLX1 is an orphan homeobox gene. It was originally discovered in association with 4-7% of cases of T cell acute lymphoblastic leukaemia’s harbouring a t(10;14)(q24;q11) cytogenetic abnormality. Research showed the presence of the TLX1 gene on chromosome 10q24 juxtaposed with the T cell receptor (TCR) delta regulatory elements on chromosome 10, resulting in aberrant over-expression of the full and intact TLX1 gene. Juxtaposition with the TCR alpha locus was also seen. Elevated TLX1 expression in leukemic blasts is also detected in the absence of a translocation in ~50% (37/76) of paediatric T-ALL cases, as well as rare cases of B-AL. Clinically, TLX1+ T-ALLs are associated with a genetic signature associated with maturation arrest at an early cortical thymocyte stage of T cell development. This model organism recapitulates many molecular features of human leukaemia’s induced by the TLX family of TF oncogenes.
Production Details The human TLX1 cDNA was amplified by PCR using BamHI restriction site containing primers and cDNA of the human T-cell leukemia cell line ALL-SIL as template and was cloned in the pUC1017 vector, downstream of the mouse T-cell specific p56Lck proximal promoter
Conditional No
Strain C57BL/6
Mouse Genetic Background/Cross History 129/Sv-C57Bl/6 mixed
Research Area Cancer, Immunology
Notes Transgenic mouse expressing human transcription factor Tlx1 in T cell progenitors under control of the LCK promoter

References

There are 2 reference entries for this reagent.

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References: 2 entries

De Keersmaecker et al. 2010. Nat Med. 16(11):1321-7. PMID: 20972433.

The TLX1 oncogene drives aneuploidy in T cell transformation.

Europe PMC ID: 20972433


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References: 2 entries

De Keersmaecker et al. 2010. Nat Med. 16(11):1321-7. PMID: 20972433.

The TLX1 oncogene drives aneuploidy in T cell transformation.


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