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Anti-CEACAM5/6/8 (CD66e/c/b) [ivi4/27] monoclonal antibody

Invented by Dr Bernhard B. Singer at LeukoCom

Info

Catalogue Number 154005
Applications ELISA FACS IHC IP WB
Antigen/Gene or Protein Targets human CEACAM 5, 6, and 8; macaque CEACAM 5
Reactivity Human
Host Mouse
Immunogen Human CEA derivative; in vitro immunisation
Subclass IgG1 kappa
Myeloma Used NS1/0
Notes CEACAMs (Carcinoembryonic antigen-related (CEA) cell adhesion molecules) are highly glycosylated membrane anchored proteins. CEACAM genes make up the CEA family belonging to the immunoglobulin superfamily. CEACAMs are involved in cell adhesion and cell-cell communication processes. CEACAM 5 and 6 but NOT CEACAM8 serve as pathogen receptors (e.g. for Helicobacter pylori, Neisseria, Moraxella, Candida albicans). Immunologically they are characterized as members of the CD66 cluster of differentiation.

Antibodies to CEACAMs are commonly used in immunohistochemistry and flow cytometry to identify cells expressing the glycoproteins. However, CEACAM 5 and 6 are also found in serum where they can serve as tumor markers. In adults CEACAM5 and 6 are expressed in epithelia and CEACAM6 and 8 in granulocytes.
Research Area Cancer, Immunology

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