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Anti-CEACAMs polyclonal antibody

Invented by Dr Bernhard B. Singer at LeukoCom

Info

Catalogue Number 154003
Applications ELISA FACS IHC IP WB
Antigen/Gene or Protein Targets LC rb-pAb CEAx, human CEACAM1, -3, -4, -5, -6, -7, -8, -18, -19, -20, rat CEACAM1, mouse CEACAM1/2
Reactivity Human, Mouse and Rat
Host Rabbit
Immunogen CEA Derivative
Concentration 3.63 mg/ml
Formulation PBS without Mg and Ca
Method of Purification Protein G purified
Notes Not suitable for Sandwich ELISA.

CEA-related cell adhesion molecules (CEACAMs) are members of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily. All CEACAMs are heavily glycosylated. The CEACAM subgroup in humans consists of 12 members composed of a single immunoglobulin variable (IgV)-like N-terminal (N) domain followed by zero to six Ig constant (IgC)-like domains of A and B subtypes and one member which consists of two IgC-like domains and two IgV-like domains, one at each end of the molecule.

CEACAMs show a very heterogeneous expression pattern and can be expressed in several leukocyte-subtypes, most epithelia and endothelia. As their expression pattern, CEACAM mediated functions are very heterogeneous and range from cell-cell communication, proliferation, apoptosis to differentiation and contact-inhibition. Most CEACAMs also serve as pathogen receptors.
Research Area Cancer, Immunology

References

There are 7 reference entries for this reagent.

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References: 7 entries

Singer B.B.: CEACAMs. Encyclopedia of Signaling Molecules. 2016.

Javaheri et al. 2016. Nat Microbiol. 2:16189. PMID: 27748768.

Helicobacter pylori adhesin HopQ engages in a virulence-enhancing interaction with human CEACAMs.

Europe PMC ID: 27748768

Beauchemin et al. 2013. Cancer Metastasis Rev. 32(3-4):643-71. PMID: 23903773.

Carcinoembryonic antigen-related cell adhesion molecules (CEACAMs) in cancer progression and metastasis.

Europe PMC ID: 23903773

Kuespert et al. 2006. Curr Opin Cell Biol. 18(5):565-71. PMID: 16919437.

CEACAMs: their role in physiology and pathophysiology.

Europe PMC ID: 16919437


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References: 7 entries

Singer B.B.: CEACAMs. Encyclopedia of Signaling Molecules. 2016.

Javaheri et al. 2016. Nat Microbiol. 2:16189. PMID: 27748768.

Helicobacter pylori adhesin HopQ engages in a virulence-enhancing interaction with human CEACAMs.

Beauchemin et al. 2013. Cancer Metastasis Rev. 32(3-4):643-71. PMID: 23903773.

Carcinoembryonic antigen-related cell adhesion molecules (CEACAMs) in cancer progression and metastasis.

Kuespert et al. 2006. Curr Opin Cell Biol. 18(5):565-71. PMID: 16919437.

CEACAMs: their role in physiology and pathophysiology.


Add a reference