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Anti-CEACAM21 [1E4] monoclonal antibody

Invented by Dr Bernhard B. Singer at LeukoCom

Info

Catalogue Number 153999
Applications ELISA FACS WB
Antigen/Gene or Protein Targets Human CEACAM 21
Reactivity Human
Host Mouse
Immunogen Recombinant soluble human CEACAM 21-Fc produced in HEK293 Transfectants
Subclass IgG1 kappa
Myeloma Used NS1/0
Notes Carcinoembryonic antigen-related cell adhesion molecule 21 (CEACAM21) is a member of the CEA gene family and thus part of the immunoglobulin (Ig) superfamily. The CEACAM21 gene codes for both the CEACAM3 and CEACAM21 proteins and is located on chromosome 19. The mature protein is highly glycosylated and contains a single IgV-like domain, common to all members of the CEACAM family, followed by one IgC2-like domain (1).

CEACAM21 is thought to be a primate-specific, and to date, no orthologs have been identified in lower species (2). The function of the CEACAM21 protein still has to be elucidated but it has been described to be overexpressed in heavy smokers (3) and is associated with COPD susceptibility (4).

1.) Tchoupa, A. et al. (2014) J Cell Commun Signal 12:27.
2.) Zebhauser, R. et al. (2005) Genomics 86:566.
3.) Fukuda, I. et al. (1998) J. Med. Syst. 22:89.
4.) Qiu, W. et al. (2011) PLoS ONE 6:e24395.
Research Area Cancer

References

There are 7 reference entries for this reagent.

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References: 7 entries

Tchoupa et al. 2014. Cell Commun Signal. 12:27. PMID: 24735478.

Signaling by epithelial members of the CEACAM family - mucosal docking sites for pathogenic bacteria.

Europe PMC ID: 24735478

Genetics of sputum gene expression in chronic obstructive pulmonary disease.

Europe PMC ID: 21949713

Qiu et al. 2011. PLoS One. 6(9):e24395. PMID: 21949713.

Zebhauser et al. 2005. Genomics. 86(5):566-80. PMID: 16139472.

Identification of a novel group of evolutionarily conserved members within the rapidly diverging murine Cea family.

Europe PMC ID: 16139472

Fukuda, I., Yamakado, M. & Kiyose, H. Journal of Medical Systems (1998) 22: 89.


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References: 7 entries

Tchoupa et al. 2014. Cell Commun Signal. 12:27. PMID: 24735478.

Signaling by epithelial members of the CEACAM family - mucosal docking sites for pathogenic bacteria.

Genetics of sputum gene expression in chronic obstructive pulmonary disease.

Qiu et al. 2011. PLoS One. 6(9):e24395. PMID: 21949713.

Zebhauser et al. 2005. Genomics. 86(5):566-80. PMID: 16139472.

Identification of a novel group of evolutionarily conserved members within the rapidly diverging murine Cea family.

Fukuda, I., Yamakado, M. & Kiyose, H. Journal of Medical Systems (1998) 22: 89.


Add a reference