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Catalogue Number 153963
Applications IF WB
Antigen/Gene or Protein Targets Dlg1
Synonyms Discs Large MAGUK Scaffold Protein, Synapse-Associated Protein 97, Discs Large Homolog 1, Scribble Cell Polarity Complex Component 2, Presynaptic Protein SAP97, Disks Large Homolog 1, SAP97
Reactivity Drosophila, Human and Rat
Relevance hDlg1 is a mammalian homolog of the Drosophila discs large tumour suppressor protein which is intimately involved in the control of cell growth, maintenance of cell adhesion and cell polarity. In cells hDlg1 associates with the cortical cytoskeleton that underlies the plasma membrane at cell-cell adhesion sites. PDZ domains of hDlg1 have been shown to interact with the C-termini of several proteins including Shaker-type K+ channels, cytoskeletal protein 4.1 and the APC tumour suppressor protein. In addition hDlg1 has also been shown to interact with several viral oncoproteins including Adenovirus 9 E4ORF1 protein, HTLV-1 Tax and the high risk HPV E6 proteins.
Host Rabbit
Immunogen N-terminus aa 1-222 of rat Dlg
Formulation Serum
Molecular Weight (kDa) 107kDa
Notes WB 1:1000
IF 1:1000
Research Area Adhesion, Cancer, Cell Signaling & Signal Transduction

References

There are 6 reference entries for this reagent.

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References: 6 entries
RECENTLY UPDATED

Narayan et al. 2009. Virology. 387(1):1-4. PMID: 19307009.

The high-risk HPV E6 oncoprotein preferentially targets phosphorylated nuclear forms of hDlg.

Europe PMC ID: 19307009

Massimi et al. 2003. Exp Cell Res. 290(2):265-74. PMID: 14567986.

Redistribution of the discs large tumor suppressor protein during mitosis.

Europe PMC ID: 14567986

Mantovani et al. 2001. J Cell Sci. 114(Pt 23):4285-92. PMID: 11739660.

Proteasome-mediated regulation of the hDlg tumour suppressor protein.

Europe PMC ID: 11739660


Add a reference

References: 6 entries
RECENTLY UPDATED

Narayan et al. 2009. Virology. 387(1):1-4. PMID: 19307009.

The high-risk HPV E6 oncoprotein preferentially targets phosphorylated nuclear forms of hDlg.

Massimi et al. 2003. Exp Cell Res. 290(2):265-74. PMID: 14567986.

Redistribution of the discs large tumor suppressor protein during mitosis.

Mantovani et al. 2001. J Cell Sci. 114(Pt 23):4285-92. PMID: 11739660.

Proteasome-mediated regulation of the hDlg tumour suppressor protein.


Add a reference