Cancer Research Technology
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R-3327-AT6.1 cell line

Info

Catalogue Number 156405
Antigen/Gene or Protein Targets Tumor suppressor genes on Human chromosome 11
Disease Keywords Prostate cancer
Model Cancer Model
Relevance Somatic cell hybrids created from highly metastatic rat prostatic cancer cells and human chromosome 11 were created using micro cell-mediated chromosome transfer. The introduction of human chromosome 11 into the highly metastatic rat prostate cancer cells suppressed the metastatic ability of the cells without suppression of the in vivo growth rate or tumorigenicity of the hybrid cells.These cell hybrids can be used to pinpoint tumor suppressor genes on human chromosome 11. The cell line may also be used to screen for drugs that target the human tumor suppressor genes expressed. Such drugs can potentially be used as chemotherapeutic or chemopreventive agents for prostate cancer.
Research Area Cancer, Drug Discovery & Development
Cellosaurus ID CVCL_4030

References

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References: 1 entry

Ichikawa et al. 1992. Cancer Res. 52(12):3486-90. PMID: 1596907.


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References: 1 entry

Ichikawa et al. 1992. Cancer Res. 52(12):3486-90. PMID: 1596907.


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