| Catalogue Number | 153776 |
| Applications | WB |
| Antigen/Gene or Protein Targets | Arachidonate 12-lipoxygenase (ALOX12B) |
| Synonyms | Arachidonate 12-lipoxygenase, 12R-type, 12R-LOX, 12R-lipoxygenase, Epidermis-type lipoxygenase 12. UniProt ID:O75342 |
| Reactivity | Human and Mouse |
| Relevance | Alox12b plays a crucial role in the synthesis of corneocytes lipid envelope and the establishment of the skin barrier to water loss. Ichthyosis is a family of rare genetic skin disorders characterised by dry, thickened, scaly skin associated with mutations in Alox12b. |
| Host | Rabbit |
| Immunogen | Mouse 12R-LOX (Y14334) Peptide Y1: aa 159-179 IPSYHPPPRRCRNPNRPEWDG Or Mouse 12R-LOX (Y14334) Peptide Y2: aa 167-189 CRNPNRPEWDGYIPGFPILINIKA |
| Formulation | Neat sera |
| Notes |
Western blot dilution: 1:5,000 Two different peptides of mouse 12R-LOX (Y14334) used as immunogens: Peptide Y1: aa 159-179 IPSYHPPPRRCRNPNRPEWDG Peptide Y2: aa 167-189 CRNPNRPEWDGYIPGFPILINIKA Sera preparations produced using the two different peptide immunogens are separate; please specify if a specific one is required. |
| Research Area | Adhesion, Cell Structure and Motility, Metabolism |
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