Cancer Research Technology
Log in Register
Menu

Alox12bf/fK14CreERT2 Mouse
RECENTLY UPDATED

Invented by Dr Peter Krieg at Deutsches Krebsforschungszentrum (DKFZ) German Cancer Research Center

Info

Catalogue Number 153757
Antigen/Gene or Protein Targets Arachidonate 12-lipoxygenase (ALOX12B)
Disease Keywords Ichthyosis, congenital, autosomal recessive 2 (ARCI2)
Synonyms Arachidonate 12-lipoxygenase, 12R-type, 12R-LOX, 12R-lipoxygenase, Epidermis-type lipoxygenase 12. UniProt ID:O75342
Model Conditional KO
Relevance Tamoxifen inducible ablation of arachidonate 12-lipoxygenase (Alox12b) in epidermis (and other K14 expressing tissues). Alox12b plays a crucial role in the synthesis of corneocytes lipid envelope and the establishment of the skin barrier to water loss. Ichthyosis, congenital, autosomal recessive 2 (ARCI2). Ichthyosis is a family of rare genetic skin disorders characterised by dry, thickened, scaly skin.
Conditional Yes
Conditional Description Tamoxifen inducible ablation of arachidonate 12-lipoxygenase (Alox12b) in epidermis (and other K14 expressing tissues) via conditional Cre-ERT2 expression under the K14 promoter.
Mouse Genetic Background/Cross History SKH1
Research Area Adhesion, Cell Structure and Motility, Drug Discovery & Development, Gene Expression, Metabolism
Notes Genetic modifications:
a) Insertion of loxP sites flanking essential exon 8 of Alox12b (=floxed Alox12b)(Epp et al., JBC 2007)
b) K14 cre/ESR1T2 (knock in) (Amen et al. Hum Mol Genet 2013)
c) Crossing of the floxed Alox12b mice with the K14Cre mice (unpublished)
d) Cross-bred with SKH1 hairless mice (unpublished)

Mouse model also known as:
Short name: SKH1/Alox12bflox/K14CreJ
Full name: STOCK-Hrhr Alox12btm1Krie Krt14tm1.1(cre/ESR1T2)#Dkfz / Krie

References

There are 2 reference entries for this reagent.

View All References

References: 2 entries

Krieg et al. 2014. Biochim Biophys Acta. 1841(3):390-400. PMID: 23954555.

The role of lipoxygenases in epidermis.

Europe PMC ID: 23954555


Add a reference

References: 2 entries

Krieg et al. 2014. Biochim Biophys Acta. 1841(3):390-400. PMID: 23954555.

The role of lipoxygenases in epidermis.


Add a reference