| Catalogue Number | 153757 |
| Antigen/Gene or Protein Targets | Arachidonate 12-lipoxygenase (ALOX12B) |
| Disease Keywords | Ichthyosis, congenital, autosomal recessive 2 (ARCI2) |
| Synonyms | Arachidonate 12-lipoxygenase, 12R-type, 12R-LOX, 12R-lipoxygenase, Epidermis-type lipoxygenase 12. UniProt ID:O75342 |
| Model | Conditional KO |
| Relevance | Tamoxifen inducible ablation of arachidonate 12-lipoxygenase (Alox12b) in epidermis (and other K14 expressing tissues). Alox12b plays a crucial role in the synthesis of corneocytes lipid envelope and the establishment of the skin barrier to water loss. Ichthyosis, congenital, autosomal recessive 2 (ARCI2). Ichthyosis is a family of rare genetic skin disorders characterised by dry, thickened, scaly skin. |
| Conditional | Yes |
| Conditional Description | Tamoxifen inducible ablation of arachidonate 12-lipoxygenase (Alox12b) in epidermis (and other K14 expressing tissues) via conditional Cre-ERT2 expression under the K14 promoter. |
| Mouse Genetic Background/Cross History | SKH1 |
| Research Area | Adhesion, Cell Structure and Motility, Drug Discovery & Development, Gene Expression, Metabolism |
| Notes |
Genetic modifications: a) Insertion of loxP sites flanking essential exon 8 of Alox12b (=floxed Alox12b)(Epp et al., JBC 2007) b) K14 cre/ESR1T2 (knock in) (Amen et al. Hum Mol Genet 2013) c) Crossing of the floxed Alox12b mice with the K14Cre mice (unpublished) d) Cross-bred with SKH1 hairless mice (unpublished) Mouse model also known as: Short name: SKH1/Alox12bflox/K14CreJ Full name: STOCK-Hrhr Alox12btm1Krie Krt14tm1.1(cre/ESR1T2)#Dkfz / Krie |
Krieg et al. 2014. Biochim Biophys Acta. 1841(3):390-400. PMID: 23954555.
The role of lipoxygenases in epidermis.
Europe PMC ID: 23954555
Krieg et al. 2014. Biochim Biophys Acta. 1841(3):390-400. PMID: 23954555.
The role of lipoxygenases in epidermis.
