Anti-Cryptococcus [crp127]
Invented by Prof Robin May from University Of Birmingham
Invented at University Of Birmingham
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Info
| Catalogue Number | 153688 |
| Applications | IF WB |
| Antigen/Gene or Protein Targets | Cryptococcus |
| Synonyms | Cryptococcal capsule, Filobasidiella |
| Reactivity | Cryptococcus gatti and Cryptococcus neoformans |
| Relevance |
Cryptococcus is a genus of fungus of where the majority of organisms are found living in the soil. Cryptococcal cells are covered in a thin gelatin-like layer of capsular glycoprotein material which serves to help extract nutrients from the surroundings. The capsule from C. neoformans which is the most prominent human and animal pathogen in the genus, is different. Its capsule has a greater composition of glucuronic acid and mannose possessing O-acetyl groups and functions as the major virulence factor contributing to cryptococcal infection and disease. The antibody recognises capsular material on the surface of the pathogenic fungi Cryptococcus gattii and C. neoformans. It does not appear to recognise the capsule on the related species C. laurentii and recognition appears to depend on O-acetylation of the capsular polysaccharide. |
| Host | Mouse |
| Immunogen | Whole, heat-killed Cryptococcus gattii R265 |
| Subclass | IgM |
| Research Area | Bacteriology, Microbiology |
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