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Anti-Cryptococcus [crp127]

Invented by Prof Robin May at University Of Birmingham

Info

Catalogue Number 153688
Applications IF WB
Antigen/Gene or Protein Targets Cryptococcus
Synonyms Cryptococcal capsule, Filobasidiella
Reactivity Cryptococcus gatti and Cryptococcus neoformans
Relevance Cryptococcus is a genus of fungus of where the majority of organisms are found living in the soil.

Cryptococcal cells are covered in a thin gelatin-like layer of capsular glycoprotein material which serves to help extract nutrients from the surroundings. The capsule from C. neoformans which is the most prominent human and animal pathogen in the genus, is different. Its capsule has a greater composition of glucuronic acid and mannose possessing O-acetyl groups and functions as the major virulence factor contributing to cryptococcal infection and disease.

The antibody recognises capsular material on the surface of the pathogenic fungi Cryptococcus gattii and C. neoformans. It does not appear to recognise the capsule on the related species C. laurentii and recognition appears to depend on O-acetylation of the capsular polysaccharide.
Host Mouse
Immunogen Whole, heat-killed Cryptococcus gattii R265
Subclass IgM
Research Area Bacteriology, Microbiology

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