Anti-Proteolipid protein [PLPC1]
Invented at
- Datasheet
- References (52)
- Inventor Info
Info
![Image thumbnail for Anti-Proteolipid protein [PLPC1]](https://res.cloudinary.com/ximbio/image/upload/c_fit,fl_lossy,h_45,q_auto/f6b57708-ead0-46bf-a3a1-87feb4cb49d6.png)
![Image thumbnail for Anti-Proteolipid protein [PLPC1]](https://res.cloudinary.com/ximbio/image/upload/c_fit,fl_lossy,h_45,q_auto/43857db8-5f9b-47a8-8ca0-eed32147c8d2.png)
![Image thumbnail for Anti-Proteolipid protein [PLPC1]](https://res.cloudinary.com/ximbio/image/upload/c_fit,fl_lossy,h_45,q_auto/4e5c2ff5-f3ee-41a6-817e-1534492e2ba6.png)
![Image thumbnail for Anti-Proteolipid protein [PLPC1]](https://res.cloudinary.com/ximbio/image/upload/c_fit,fl_lossy,h_45,q_auto/c1972751-bca3-47a8-adf3-3ab5c1877857.png)
![Image thumbnail for Anti-Proteolipid protein [PLPC1]](https://res.cloudinary.com/ximbio/image/upload/c_fit,fl_lossy,h_45,q_auto/7ed30689-e0ba-4a38-8a41-6ae80e1906eb.png)
![Image thumbnail for Anti-Proteolipid protein [PLPC1]](https://res.cloudinary.com/ximbio/image/upload/c_fit,fl_lossy,h_45,q_auto/b002a270-2672-4bdd-8946-72c8cb6f5bf1.png)
![Image thumbnail for Anti-Proteolipid protein [PLPC1]](https://res.cloudinary.com/ximbio/image/upload/c_fit,fl_lossy,h_45,q_auto/e1055e64-c5aa-4ecc-9d0c-5cdf517a9567.png)
![Image thumbnail for Anti-Proteolipid protein [PLPC1]](https://res.cloudinary.com/ximbio/image/upload/c_fit,fl_lossy,h_45,q_auto/ea823f0e-87a1-4da6-8052-cc08774e036b.png)
| Catalogue Number | 153649 |
| Applications | FACS IHC IF WB |
| Antigen/Gene or Protein Targets | Myelin Proteolipid protein |
| Synonyms | Myelin proteolipid protein, PLP, Lipophilin, PLP1 |
| Reactivity | Human and Tenerife lizard (Gallotia galloti) |
| Relevance | Proteolipid protein (PLP) is the major myelin protein of the CNS and plays an important role in the formation and maintenance of myelin. Mutations in PLP gene can lead to dysmyelinating diseases. Clone PLPC1 is used in the detection of PLP by various analysis methods. |
| Host | Mouse |
| Immunogen | Synthetic peptide GRGTKF that recognizes the C terminal region of myelin proteolipid protein |
| Positive Control | Brain tissue |
| Subclass | IgG2a |
| Molecular Weight (kDa) | 23-25 |
| Myeloma Used | Sp2/0-Ag14 |
| Strain | Balb/c |
| Notes |
Suggested dilutions for use Western Blot 1:250 Immunohistochemistry 1:200-1:3000 Immunofluorescence Assay-dependent Immunocytochemistry 1:1000 - 1:1500 Research Areas: Immunology;Neurobiology;Cardiovascular; Infectious Diseases |
| Research Area | Cardiovascular, Immunology, Neurobiology |
References: 52 entries
Maccarrone et al. 2017. J Chromatogr B Analyt Technol Biomed Life Sci. 1047:131-140. PMID: 27461358.
Cerina et al. 2017. Brain Behav Immun. 59:103-117. PMID: 27569659.
The quality of cortical network function recovery depends on localization and degree of axonal demyelination.
Europe PMC ID: 27569659
Chuang et al. 2016. Acta Neuropathol Commun. 4(1):68. PMID: 27400748.
LRP1 expression in microglia is protective during CNS autoimmunity.
Europe PMC ID: 27400748
MALDI imaging mass spectrometry analysis-A new approach for protein mapping in multiple sclerosis brain lesions.
Europe PMC ID: 27461358
Janssen et al. 2016. Mol Neurobiol. 53(3):1551-1564. PMID: 25663168.
Höftberger et al. 2015. Acta Neuropathol Commun. 3:80. PMID: 26637427.
Autoimmune encephalitis in humans: how closely does it reflect multiple sclerosis ?
Europe PMC ID: 26637427
Absence of CCL2 and CCL3 Ameliorates Central Nervous System Grey Matter But Not White Matter Demyelination in the Presence of an Intact Blood-Brain Barrier.
Europe PMC ID: 25663168
Identification of synaptosomal proteins binding to monomeric and oligomeric α-synuclein.
Europe PMC ID: 25659148
Betzer et al. 2015. PLoS One. 10(2):e0116473. PMID: 25659148.
7 Tesla magnetic resonance imaging to detect cortical pathology in multiple sclerosis.
Europe PMC ID: 25303286
García-Vallejo et al. 2014. J Exp Med. 211(7):1465-83. PMID: 24935259.
FACS
CNS myelin induces regulatory functions of DC-SIGN-expressing, antigen-presenting cells via cognate interaction with MOG.
Europe PMC ID: 24935259
Yao et al. 2014. PLoS One. 9(10):e108863. PMID: 25303286.
Skripuletz et al. 2013. Brain. 136(Pt 1):147-67. PMID: 23266461.
Astrocytes regulate myelin clearance through recruitment of microglia during cuprizone-induced demyelination.
Europe PMC ID: 23266461
Kooi et al. 2012. Neurology. 79(13):1369-76. PMID: 22972651.
Heterogeneity of cortical lesions in multiple sclerosis: clinical and pathologic implications.
Europe PMC ID: 22972651
van Horssen et al. 2012. J Neuroinflammation. 9:156. PMID: 22747960.
Clusters of activated microglia in normal-appearing white matter show signs of innate immune activation.
Europe PMC ID: 22747960
Seewann et al. 2012. Neurology. 78(5):302-8. PMID: 22218278.
Postmortem verification of MS cortical lesion detection with 3D DIR.
Europe PMC ID: 22218278
Bagnato et al. 2011. Brain. 134(Pt 12):3602-15. PMID: 22171355.
Tracking iron in multiple sclerosis: a combined imaging and histopathological study at 7 Tesla.
Europe PMC ID: 22171355
Kooi et al. 2011. Acta Neuropathol. 122(3):313-22. PMID: 21691765.
Haider et al. 2011. Brain. 134(Pt 7):1914-24. PMID: 21653539.
Cholinergic imbalance in the multiple sclerosis hippocampus.
Europe PMC ID: 21691765
Oxidative damage in multiple sclerosis lesions.
Europe PMC ID: 21653539
Kooij et al. 2011. Brain. 134(Pt 2):555-70. PMID: 21183485.
Adenosine triphosphate-binding cassette transporters mediate chemokine (C-C motif) ligand 2 secretion from reactive astrocytes: relevance to multiple sclerosis pathogenesis.
Europe PMC ID: 21183485
Bramow et al. 2010. Brain. 133(10):2983-98. PMID: 20855416.
Demyelination versus remyelination in progressive multiple sclerosis.
Europe PMC ID: 20855416
Coulpier et al. 2010. J Neurosci. 30(17):5958-67. PMID: 20427655.
CNS/PNS boundary transgression by central glia in the absence of Schwann cells or Krox20/Egr2 function.
Europe PMC ID: 20427655
Geurts et al. 2007. J Neuropathol Exp Neurol. 66(9):819-27. PMID: 17805012.
Extensive hippocampal demyelination in multiple sclerosis.
Europe PMC ID: 17805012
Roemer et al. 2007. Brain. 130(Pt 5):1194-205. PMID: 17282996.
Pattern-specific loss of aquaporin-4 immunoreactivity distinguishes neuromyelitis optica from multiple sclerosis.
Europe PMC ID: 17282996
Gilmore et al. 2006. Brain Pathol. 16(3):202-8. PMID: 16911477.
Spinal cord gray matter demyelination in multiple sclerosis-a novel pattern of residual plaque morphology.
Europe PMC ID: 16911477
Jatana et al. 2006. Pediatr Res. 59(5):684-9. PMID: 16627882.
Combination of systemic hypothermia and N-acetylcysteine attenuates hypoxic-ischemic brain injury in neonatal rats.
Europe PMC ID: 16627882
Expression of recombinant forms of human 21.5 kDa myelin basic protein and proteolipid protein in CHO cells.
Europe PMC ID: 16302025
Jaśkiewicz et al. 2005. Acta Biochim Pol. 52(4):863-6. PMID: 16302025.
FACS
Massa et al. 2002. J Virol. 76(16):8335-46. PMID: 12134038.
Critical role for protein tyrosine phosphatase SHP-1 in controlling infection of central nervous system glia and demyelination by Theiler's murine encephalomyelitis virus.
Europe PMC ID: 12134038
Van der Goes et al. 1999. J Neuroimmunol. 101(1):61-7. PMID: 10580814.
FACS
The role of anti-myelin (auto)-antibodies in the phagocytosis of myelin by macrophages.
Europe PMC ID: 10580814
Cheng et al. 1998. J Neurosci. 18(15):5673-81. PMID: 9671658.
Biochemical and morphometric analyses show that myelination in the insulin-like growth factor 1 null brain is proportionate to its neuronal composition.
Europe PMC ID: 9671658
Add a reference
References: 52 entries
Maccarrone et al. 2017. J Chromatogr B Analyt Technol Biomed Life Sci. 1047:131-140. PMID: 27461358.
Cerina et al. 2017. Brain Behav Immun. 59:103-117. PMID: 27569659.
The quality of cortical network function recovery depends on localization and degree of axonal demyelination.
Chuang et al. 2016. Acta Neuropathol Commun. 4(1):68. PMID: 27400748.
LRP1 expression in microglia is protective during CNS autoimmunity.
MALDI imaging mass spectrometry analysis-A new approach for protein mapping in multiple sclerosis brain lesions.
Janssen et al. 2016. Mol Neurobiol. 53(3):1551-1564. PMID: 25663168.
Höftberger et al. 2015. Acta Neuropathol Commun. 3:80. PMID: 26637427.
Autoimmune encephalitis in humans: how closely does it reflect multiple sclerosis ?
Absence of CCL2 and CCL3 Ameliorates Central Nervous System Grey Matter But Not White Matter Demyelination in the Presence of an Intact Blood-Brain Barrier.
Identification of synaptosomal proteins binding to monomeric and oligomeric α-synuclein.
Betzer et al. 2015. PLoS One. 10(2):e0116473. PMID: 25659148.
7 Tesla magnetic resonance imaging to detect cortical pathology in multiple sclerosis.
García-Vallejo et al. 2014. J Exp Med. 211(7):1465-83. PMID: 24935259.
FACS
CNS myelin induces regulatory functions of DC-SIGN-expressing, antigen-presenting cells via cognate interaction with MOG.
Yao et al. 2014. PLoS One. 9(10):e108863. PMID: 25303286.
Skripuletz et al. 2013. Brain. 136(Pt 1):147-67. PMID: 23266461.
Astrocytes regulate myelin clearance through recruitment of microglia during cuprizone-induced demyelination.
Kooi et al. 2012. Neurology. 79(13):1369-76. PMID: 22972651.
Heterogeneity of cortical lesions in multiple sclerosis: clinical and pathologic implications.
van Horssen et al. 2012. J Neuroinflammation. 9:156. PMID: 22747960.
Clusters of activated microglia in normal-appearing white matter show signs of innate immune activation.
Seewann et al. 2012. Neurology. 78(5):302-8. PMID: 22218278.
Postmortem verification of MS cortical lesion detection with 3D DIR.
Bagnato et al. 2011. Brain. 134(Pt 12):3602-15. PMID: 22171355.
Tracking iron in multiple sclerosis: a combined imaging and histopathological study at 7 Tesla.
Kooi et al. 2011. Acta Neuropathol. 122(3):313-22. PMID: 21691765.
Haider et al. 2011. Brain. 134(Pt 7):1914-24. PMID: 21653539.
Cholinergic imbalance in the multiple sclerosis hippocampus.
Oxidative damage in multiple sclerosis lesions.
Kooij et al. 2011. Brain. 134(Pt 2):555-70. PMID: 21183485.
Adenosine triphosphate-binding cassette transporters mediate chemokine (C-C motif) ligand 2 secretion from reactive astrocytes: relevance to multiple sclerosis pathogenesis.
Bramow et al. 2010. Brain. 133(10):2983-98. PMID: 20855416.
Demyelination versus remyelination in progressive multiple sclerosis.
Coulpier et al. 2010. J Neurosci. 30(17):5958-67. PMID: 20427655.
CNS/PNS boundary transgression by central glia in the absence of Schwann cells or Krox20/Egr2 function.
Geurts et al. 2007. J Neuropathol Exp Neurol. 66(9):819-27. PMID: 17805012.
Extensive hippocampal demyelination in multiple sclerosis.
Roemer et al. 2007. Brain. 130(Pt 5):1194-205. PMID: 17282996.
Pattern-specific loss of aquaporin-4 immunoreactivity distinguishes neuromyelitis optica from multiple sclerosis.
Gilmore et al. 2006. Brain Pathol. 16(3):202-8. PMID: 16911477.
Spinal cord gray matter demyelination in multiple sclerosis-a novel pattern of residual plaque morphology.
Jatana et al. 2006. Pediatr Res. 59(5):684-9. PMID: 16627882.
Combination of systemic hypothermia and N-acetylcysteine attenuates hypoxic-ischemic brain injury in neonatal rats.
Expression of recombinant forms of human 21.5 kDa myelin basic protein and proteolipid protein in CHO cells.
Jaśkiewicz et al. 2005. Acta Biochim Pol. 52(4):863-6. PMID: 16302025.
FACS
Massa et al. 2002. J Virol. 76(16):8335-46. PMID: 12134038.
Critical role for protein tyrosine phosphatase SHP-1 in controlling infection of central nervous system glia and demyelination by Theiler's murine encephalomyelitis virus.
Van der Goes et al. 1999. J Neuroimmunol. 101(1):61-7. PMID: 10580814.
FACS
The role of anti-myelin (auto)-antibodies in the phagocytosis of myelin by macrophages.
Cheng et al. 1998. J Neurosci. 18(15):5673-81. PMID: 9671658.
Biochemical and morphometric analyses show that myelination in the insulin-like growth factor 1 null brain is proportionate to its neuronal composition.
Add a reference