Anti-CD11a [BU17]
Invented by Dr Margaret Goodall from University Of Birmingham
Invented at University Of Birmingham
- Datasheet
- References (4)
- Inventor Info
Info
| Catalogue Number | 153581 |
| Applications | FACS |
| Antigen/Gene or Protein Targets | CD11a |
| Synonyms | Integrin alpha L; lymphocyte function-associated antigen 1 alpha polypeptide; ITGAL; cell differentiation 11a |
| Reactivity | Human |
| Relevance | CD11A encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of alpha and beta chains. This L-domain containing alpha integrin combines with the beta 2 chain to form the integrin lymphocyte function-associated antigen-1 expressed on all leukocytes and this plays a central role in leukocyte intercellular adhesion through interactions with its ligands. |
| Host | Mouse |
| Immunogen | Waldenstroms macroglobulinaemia a late B cell line with surface and secreted IgM Kappa |
| Subclass | IgG1 |
| Notes | Fusion partner: 653 |
| Research Area | Cell Signaling & Signal Transduction |
References: 4 entries
Rezzonico et al. 2001. Blood. 97(10):2932-40. PMID: 11342414.
Ligation of CD11b and CD11c beta(2) integrins by antibodies or soluble CD23 induces macrophage inflammatory protein 1alpha (MIP-1alpha) and MIP-1beta production in primary human monocytes through a pathway dependent on nuclear factor-kappaB.
Europe PMC ID: 11342414
Baker et al. 1998. Blood. 92(8):2830-43. PMID: 9763568.
Prolonged phenotypic, functional, and molecular change in group I Burkitt lymphoma cells on short-term exposure to CD40 ligand.
Europe PMC ID: 9763568
Add a reference
References: 4 entries
Rezzonico et al. 2001. Blood. 97(10):2932-40. PMID: 11342414.
Ligation of CD11b and CD11c beta(2) integrins by antibodies or soluble CD23 induces macrophage inflammatory protein 1alpha (MIP-1alpha) and MIP-1beta production in primary human monocytes through a pathway dependent on nuclear factor-kappaB.
Baker et al. 1998. Blood. 92(8):2830-43. PMID: 9763568.
Prolonged phenotypic, functional, and molecular change in group I Burkitt lymphoma cells on short-term exposure to CD40 ligand.
Add a reference
