#153581

Anti-CD11a [BU17]

Cat. #153581

Anti-CD11a [BU17]

Cat. #: 153581

Sub-type: Primary antibody

Unit size: 100 ug

Availability: 3-4 weeks

Target: CD11a

Class: Monoclonal

Application: FACS

Reactivity: Human

Host: Mouse

£300.00

This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.

Contributor

Inventor: Margaret Goodall

Institute: University of Birmingham

Tool Details
Target Details
Applications
Handling
References

Tool Details

*FOR RESEARCH USE ONLY

  • Name: Anti-CD11a [BU17]
  • Alternate name: Integrin alpha L; lymphocyte function-associated antigen 1 alpha polypeptide; ITGAL; cell differentiation 11a
  • Tool sub type: Primary antibody
  • Class: Monoclonal
  • Conjugation: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Application: FACS
  • Description: CD11A encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of alpha and beta chains. This L-domain containing alpha integrin combines with the beta 2 chain to form the integrin lymphocyte function-associated antigen-1 expressed on all leukocytes and this plays a central role in leukocyte intercellular adhesion through interactions with its ligands.
  • Immunogen: Waldenstroms macroglobulinaemia a late B cell line with surface and secreted IgM Kappa
  • Isotype: IgG1

Target Details

  • Target: CD11a
  • Target background: CD11A encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of alpha and beta chains. This L-domain containing alpha integrin combines with the beta 2 chain to form the integrin lymphocyte function-associated antigen-1 expressed on all leukocytes and this plays a central role in leukocyte intercellular adhesion through interactions with its ligands.

Applications

  • Application: FACS

Handling

  • Format: Liquid
  • Concentration: 0.9-1.1 mg/ml
  • Unit size: 100 ug
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15° C to -25° C
  • Shipping conditions: Shipping at 4° C

References

  • Rezzonico et al. 2001. Blood. 97(10):2932-40. PMID: 11342414.
  • Ligation of CD11b and CD11c beta(2) integrins by antibodies or soluble CD23 induces macrophage inflammatory protein 1alpha (MIP-1alpha) and MIP-1beta production in primary human monocytes through a pathway dependent on nuclear factor-kappaB.
  • Baker et al. 1998. Blood. 92(8):2830-43. PMID: 9763568.
  • Prolonged phenotypic, Fn, and molecular change in group I Burkitt lymphoma cells on short-term exposure to CD40 ligand.