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Anti-Sufu, Polyclonal

Info

Catalogue Number 153541
Applications WB
Antigen/Gene or Protein Targets Sufu (UniProt ID: Q9UMX1)
Synonyms Suppressor of fused homolog, SUFUH
Reactivity Human and Mouse
Relevance Sufu is a negative regulator in the hedgehog signaling pathway which directs cell proliferation and patterning during embryogenesis. Sufu down-regulates GLI1- and GLI2-mediated transactivation of target genes and is part of a corepressor complex that acts on DNA-bound GLI1. Required for normal embryonic development. Sufu is ubiquitous in adult tissues.

Heterozygous loss of Sufu, in conjunction with the loss of p53, leads to the development of medulloblastoma and rhabdomyosarcoma. Somatic Sufu mutations have been identified in multiple other malignancies, including prostate cancer.
Host Rabbit
Immunogen Sufu peptide: Hu #347~360: CLESDSSTAIIPHEL (non-phosphorylated)
Concentration 2mg/ml
Method of Purification Affinity purified
Notes Dilution used for western blot: 1:500
Research Area Cancer, Developmental Biology, Gene Expression

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