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Anti-Stat1α-C, Polyclonal

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Catalogue Number 153533
Applications IP
Antigen/Gene or Protein Targets C terminus of signal transducer and activator of transcription 1
Synonyms STAT1, CANDF7, IMD31A, IMD31B, IMD31C, ISGF-3, STAT91, signal transducer and activator of transcription 1
Reactivity Human
Relevance In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. STAT1 can be activated by several ligands such as Interferon alpha, Interferon gamma, Platelet Derived Growth Factor, Interleukin 6 or Epidermal Growth Factor. STAT1 has a key role in expressing many genes involved in survival of the cell, viability or pathogen response. Through alternative splicing there are two possible transcripts which encode 2 isoforms of STAT1. The compound, diallyl disulphide, found in garlic can induce STAT1 phosphorylation.
Host Rabbit
Immunogen GST fusion protein comprising the 39 C-terminal amino acids of Stat1α
Formulation Serum
Research Area Cell Signaling & Signal Transduction

References

There are 2 reference entries for this reagent.

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References: 2 entries

Kovarik et al. 1998. EMBO J. 17(13):3660-8. PMID: 9649436.

Stat1 combines signals derived from IFN-gamma and LPS receptors during macrophage activation.

Europe PMC ID: 9649436


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References: 2 entries

Kovarik et al. 1998. EMBO J. 17(13):3660-8. PMID: 9649436.

Stat1 combines signals derived from IFN-gamma and LPS receptors during macrophage activation.


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