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Anti-IFN-γrel [VAB4P2B4*E8]

Invented by Ayham Alnabulsi at Vertebrate Antibodies Limited

Info

Catalogue Number 153451
Applications ELISA IHC WB
Antigen/Gene or Protein Targets Anti-IFN-γrel
Synonyms IFG antibody, IFI antibody, IFN gamma antibody, IFN immune antibody, IFN-gamma antibody, IFNG antibody, Immune interferon antibody, Interferon gamma antibody
Reactivity Salmon and Brown Trout
Relevance Interferons (IFNs) were originally identified as proteins that induce an antiviral state in cells, but they also have important regulatory functions in the immune system. Type I IFN (predominantly IFN-α and IFN-β) and type II IFN (IFN-γ) play critical roles in innate and adaptive immune response against viral infection in mammals. Unlike mammals fish have two type II interferons, IFN-γ and IFN-γ-related (IFN-γrel). IFN-γ and IFN-γrel have recently been shown to play a role in protecting particular species of fish against infection by pathogens such as infectious pancreatic necrosis virus (IPNV) and salmonid alphavirus 3 (SAV3). VAB4P2B4*E8 can be used to study IFN-γrel in Atlantic salmon (Salmo salar) and Brown trout (Salmo trutta).
Host Mouse
Immunogen ovalbumin-conjugated synthetic peptide-DLKRSYYQDR; peptide immunogen is 90% identical to rainbow trout (Oncorhynchus mykiss)
Positive Control Western Blot-IFN-γrel recombinant; IHC- Formalin-fixed, paraffin-embedded fish head kidney and spleen
Subclass IgG
Molecular Weight (kDa) 22 kDa
Myeloma Used P3X63Ag8.653
Strain Balb/c
Notes Recommended Usage Conditions: ELISA- neat, Western Blot- neat, IHC- 1/3, antigen retrieval: microwave 20 min @ 800W in 10 mM citrate buffer, pH 6.0
Research Area Aquaculture, Immunology

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