Fibroblast Growth Factor Receptor 2, Isoform 1, aa 22-377, Protein
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|Amino Acid Sequence||FGFR2 Isoform 1, amino acids 22-377, Uniprot ID P21802-1, with C-terminal 10xHis tag|
|Source||Expressed in human embryo kidney cell line HEK293|
Human Fibroblast Growth Factor Receptor (FGFR) 2 Isoform 1, amino acids 22-377 with C-terminal 10xHistidine tag. This is one of a series of soluble domains of isoforms of human FGFRs expressed in the Human Embryo Kidney cell line HEK293. Uniprot No. P21802-1.
Fibroblast growth factor receptor 2 (FGFR2) is a tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Required for normal embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis and skin development. Plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. Promotes cell proliferation in keratinocytes and immature osteoblasts, but promotes apoptosis in differentiated osteoblasts. Phosphorylates PLCG1, FRS2 and PAK4. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. FGFR2 signaling is down-regulated by ubiquitination, internalization and degradation. Mutations that lead to constitutive kinase activation or impair normal FGFR2 maturation, internalization and degradation lead to aberrant signaling. Over-expressed FGFR2 promotes activation of STAT1.
|Antigen/Gene or Protein Targets||Fibroblast Growth Factor Receptor 2, Isoform 1|
|Research Area||Cell Signaling & Signal Transduction, Cell Structure and Motility, Developmental Biology, Epitope Tags, Gene Expression, Metabolism|
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