| Amino Acid Sequence | FGFR1, Isoform 14, amino acids 22-375, Uniprot ID P11362-7, with C-terminal 10xHis tag |
| Source | Expressed in human embryo kidney cell line HEK293 |
| Relevance |
Human Fibroblast Growth Factor Receptor (FGFR) 1 Isoform 14, amino acids 22-375 with C-terminal 10xHistidine tag. This is one of a series of soluble domains of isoforms of human FGFRs expressed in the Human Embryo Kidney cell line HEK293. Uniprot No. P11362-7. Fibroblast Growth Factor Receptor 1 (FGFR1) is a tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2. In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription. FGFR1 signaling is down-regulated by IL17RD/SEF, and by FGFR1 ubiquitination, internalization and degradation. |
| Antigen/Gene or Protein Targets | Fibroblast Growth Factor Receptor 1, Isoform 14 |
| Research Area | Cell Signaling & Signal Transduction, Cell Structure and Motility, Developmental Biology, Epitope Tags, Gene Expression, Metabolism |
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