Anti-EGFR [ICR10]
Invented at The Institute of Cancer Research
- Datasheet
- References (2)
- Inventor Info
Info
| Catalogue Number | 153386 |
| Applications | FACS IHC WB |
| Antigen/Gene or Protein Targets | EGFR |
| Synonyms | ERBB1; HER1; epidermal growth factor receptor; ERBB; mENA; PIG61 |
| Reactivity | Human |
| Relevance | The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. Multiple alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. |
| Host | Rat |
| Immunogen | Extracellular domain of human EGF-receptor from head and neck carcinoma |
| Positive Control | FACS: A431 cells IHC: Breast Carcinoma tissue WB: HN5 cell lysate |
| Subclass | IgG2a |
| Research Area | Cancer, Cell Signaling & Signal Transduction |
References: 2 entries
Modjtahedi et al. 2012. Br J Cancer. 106(5):883-8. PMID: 22315050.
Immunohistochemical discrimination of wild-type EGFR from EGFRvIII in fixed tumour specimens using anti-EGFR mAbs ICR9 and ICR10.
Europe PMC ID: 22315050
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References: 2 entries
Modjtahedi et al. 2012. Br J Cancer. 106(5):883-8. PMID: 22315050.
Immunohistochemical discrimination of wild-type EGFR from EGFRvIII in fixed tumour specimens using anti-EGFR mAbs ICR9 and ICR10.
Add a reference
