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Anti-EGFR [ICR10]

Info

Catalogue Number 153386
Applications FACS IHC WB
Antigen/Gene or Protein Targets EGFR
Synonyms ERBB1; HER1; epidermal growth factor receptor; ERBB; mENA; PIG61
Reactivity Human
Relevance The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. Multiple alternatively spliced transcript variants that encode different protein isoforms have been found for this gene.
Host Rat
Immunogen Extracellular domain of human EGF-receptor from head and neck carcinoma
Positive Control FACS: A431 cells IHC: Breast Carcinoma tissue WB: HN5 cell lysate
Subclass IgG2a
Research Area Cancer, Cell Signaling & Signal Transduction

References

There are 2 reference entries for this reagent.

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References: 2 entries

Modjtahedi et al. 2012. Br J Cancer. 106(5):883-8. PMID: 22315050.

Immunohistochemical discrimination of wild-type EGFR from EGFRvIII in fixed tumour specimens using anti-EGFR mAbs ICR9 and ICR10.

Europe PMC ID: 22315050


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References: 2 entries

Modjtahedi et al. 2012. Br J Cancer. 106(5):883-8. PMID: 22315050.

Immunohistochemical discrimination of wild-type EGFR from EGFRvIII in fixed tumour specimens using anti-EGFR mAbs ICR9 and ICR10.


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