Cat. #153386
Anti-EGFR [ICR10]
Cat. #: 153386
Sub-type: Primary antibody
Unit size: 100 ug
Availability: 3-4 weeks
Target: EGFR
Class: Monoclonal
Application: FACS ; IHC ; WB
Reactivity: Human
Host: Rat
£300.00
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Inventor: Chris Dean
Institute: The Institute of Cancer Research
Tool Details
*FOR RESEARCH USE ONLY
- Name: Anti-EGFR [ICR10]
- Alternate name: ERBB1; HER1; epidermal growth factor receptor; ERBB; mENA; PIG61
- Clone: ICR10
- Tool sub type: Primary antibody
- Class: Monoclonal
- Conjugation: Unconjugated
- Reactivity: Human
- Host: Rat
- Application: FACS ; IHC ; WB
- Description: The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. Multiple alternatively spliced transcript variants that encode different protein isoforms have been found for this gene.
- Immunogen: Extracellular domain of human EGF-receptor from head and neck carcinoma
- Isotype: IgG2a
- Recommended controls: FACS: A431 cells IHC: Breast Carcinoma tissue WB: HN5 cell lysate
Target Details
- Target: EGFR
- Tissue cell line specificity: FACS: A431 cells IHC: Breast Carcinoma tissue WB: HN5 cell lysate
- Target background: The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. Multiple alternatively spliced transcript variants that encode different protein isoforms have been found for this gene.
Applications
- Application: FACS ; IHC ; WB
Handling
- Format: Liquid
- Concentration: 0.9-1.1 mg/ml
- Unit size: 100 ug
- Storage buffer: PBS with 0.02% azide
- Storage conditions: -15° C to -25° C
- Shipping conditions: Shipping at 4° C
References
- Modjtahedi et al. 2012. Br J Cancer. 106(5):883-8. PMID: 22315050.
- Immunohistochemical discrimination of wild-type EGFR from EGFRvIII in fixed tumour specimens using anti-EGFR mAbs ICR9 and ICR10.
