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Anti-CEACAM1 [11-1H]

Invented by Dr Bernhard B. Singer at LeukoCom

Info

Catalogue Number 153378
Applications ELISA FACS IHC IF IP WB
Antigen/Gene or Protein Targets CEACAM1
Synonyms CD66, BGP 1, BGP, CD66a, Carcinoembryonic Antigen Related Cell Adhesion Molecule 1; CD66a Antigen; BGP1; BGP; Biliary Glycoprotein 1; Antigen CD66
Reactivity Rat
Relevance Carcinoembryonic antigen related cell adhesion molecules (CEACAM) (CD66a) belong to the immunoglobulin superfamily. They are highly glycosylated proteins with the typical N-terminal variable Ig-like domain followed by 0-6 constant Ig-like domains. A hydrophobic transmembrane domain with a cytoplasmic tail anchors CEACAM1 to the cell membrane. CEACAM1 is known as an epithelial tumour suppressor and an angiogenic growth factor.
Host Mouse
Immunogen Recombinant soluble rat CEACAM1-Fc produced in HEK293 cells
Subclass IgG1 kappa
Positive Control lysate from rat bladder cell line endogenously expressing ratCEACAM1
Myeloma Used NS1/0
Strain Balb/c
Notes Does not cross-react with human CEACAM-1, -3. -4, -5, -6, 7 and -8, mouse CEACAM1 and mouse CEACAM2.
Does not bind to the N-domain of rat CEACAM1.
Research Area Adhesion, Cancer, Cell Type or Organelle Marker

References: 4 entries

Singer et al. 2005. Eur J Immunol. 35(6):1949-59. PMID: 15909305.

CEACAM1 (CD66a) mediates delay of spontaneous and Fas ligand-induced apoptosis in granulocytes.

Europe PMC ID: 15909305

Singer et al. 2000. Cancer Res. 60(5):1236-44. PMID: 10728682.

The tumor growth-inhibiting cell adhesion molecule CEACAM1 (C-CAM) is differently expressed in proliferating and quiescent epithelial cells and regulates cell proliferation.

Europe PMC ID: 10728682


Add a reference

References: 4 entries

Singer et al. 2005. Eur J Immunol. 35(6):1949-59. PMID: 15909305.

CEACAM1 (CD66a) mediates delay of spontaneous and Fas ligand-induced apoptosis in granulocytes.

Europe PMC ID: 15909305

Singer et al. 2000. Cancer Res. 60(5):1236-44. PMID: 10728682.

The tumor growth-inhibiting cell adhesion molecule CEACAM1 (C-CAM) is differently expressed in proliferating and quiescent epithelial cells and regulates cell proliferation.

Europe PMC ID: 10728682


Add a reference

References: 4 entries

Singer et al. 2005. Eur J Immunol. 35(6):1949-59. PMID: 15909305.

CEACAM1 (CD66a) mediates delay of spontaneous and Fas ligand-induced apoptosis in granulocytes.

Singer et al. 2000. Cancer Res. 60(5):1236-44. PMID: 10728682.

The tumor growth-inhibiting cell adhesion molecule CEACAM1 (C-CAM) is differently expressed in proliferating and quiescent epithelial cells and regulates cell proliferation.


Add a reference


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