Anti-CEACAM1 (CD66a) [11-1H] monoclonal antibody
Invented by Dr Bernhard B. Singer from LeukoCom
Invented at LeukoCom
- Datasheet
- References (4)
- Inventor Info
Info
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| Catalogue Number | 153378 |
| Applications | ELISA FACS IHC IF IP WB |
| Antigen/Gene or Protein Targets | CEACAM1 |
| Synonyms | CD66, BGP 1, BGP, CD66a, Carcinoembryonic Antigen Related Cell Adhesion Molecule 1; CD66a Antigen; BGP1; BGP; Biliary Glycoprotein 1; Antigen CD66 |
| Reactivity | Rat |
| Relevance | Carcinoembryonic antigen related cell adhesion molecules (CEACAM) (CD66a) belong to the immunoglobulin superfamily. They are highly glycosylated proteins with the typical N-terminal variable Ig-like domain followed by 0-6 constant Ig-like domains. A hydrophobic transmembrane domain with a cytoplasmic tail anchors CEACAM1 to the cell membrane. CEACAM1 is known as an epithelial tumour suppressor and an angiogenic growth factor. |
| Host | Mouse |
| Immunogen | Recombinant soluble rat CEACAM1-Fc produced in HEK293 cells |
| Positive Control | lysate from rat bladder cell line endogenously expressing ratCEACAM1 |
| Subclass | IgG1 kappa |
| Myeloma Used | NS1/0 |
| Strain | Balb/c |
| Notes |
Does not cross-react with human CEACAM-1, -3. -4, -5, -6, 7 and -8, mouse CEACAM1 and mouse CEACAM2. Does not bind to the N-domain of rat CEACAM1. |
| Research Area | Adhesion, Cancer, Cell Type or Organelle Marker |
References: 4 entries
Singer et al. 2005. Eur J Immunol. 35(6):1949-59. PMID: 15909305.
CEACAM1 (CD66a) mediates delay of spontaneous and Fas ligand-induced apoptosis in granulocytes.
Europe PMC ID: 15909305
Singer et al. 2000. Cancer Res. 60(5):1236-44. PMID: 10728682.
The tumor growth-inhibiting cell adhesion molecule CEACAM1 (C-CAM) is differently expressed in proliferating and quiescent epithelial cells and regulates cell proliferation.
Europe PMC ID: 10728682
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References: 4 entries
Singer et al. 2005. Eur J Immunol. 35(6):1949-59. PMID: 15909305.
CEACAM1 (CD66a) mediates delay of spontaneous and Fas ligand-induced apoptosis in granulocytes.
Singer et al. 2000. Cancer Res. 60(5):1236-44. PMID: 10728682.
The tumor growth-inhibiting cell adhesion molecule CEACAM1 (C-CAM) is differently expressed in proliferating and quiescent epithelial cells and regulates cell proliferation.
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