Anti-IL21 [V28P5G1*C4]
Invented by Ayham Alnabulsi from Vertebrate Antibodies Limited
Invented at Vertebrate Antibodies Limited
- Datasheet
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Info
![Western blot data shows Anti-IL21 [V28P5G1*C4] specifically recognizes recombinant IL21 (expected size 20 KDa)](https://res.cloudinary.com/ximbio/image/upload/c_fit,fl_lossy,q_auto/531e3dec-77de-4cae-b5fa-21b3e21f3224.png)
![Western blot data shows Anti-IL21 [V28P5G1*C4] specifically recognizes recombinant IL21 (expected size 20 KDa)](https://res.cloudinary.com/ximbio/image/upload/c_limit,fl_lossy,h_282,q_auto,w_368/531e3dec-77de-4cae-b5fa-21b3e21f3224.png)
![Image thumbnail for Anti-IL21 [V28P5G1*C4]](https://res.cloudinary.com/ximbio/image/upload/c_fit,fl_lossy,h_45,q_auto/531e3dec-77de-4cae-b5fa-21b3e21f3224.png)
| Catalogue Number | 153375 |
| Applications | ELISA IHC WB |
| Antigen/Gene or Protein Targets | Interleukin 21 (IL21) |
| Synonyms | IL 21 antibody, Interleukin 21 antibody, Interleukin21 antibody |
| Reactivity | Salmon and Rainbow Trout |
| Relevance | IL21 is a member of the type I cytokine family, which includes IL2 and IL15. IL21 signals through the common gamma-chain and a unique IL21 receptor. The IL21 receptor is expressed in cells lymphoid-lineage and regulates the proliferation and differentiation of T and B lymphocytes. Studies suggest that IL21 is a key component of CD4 T cell help that is required for maintaining the CD8+ T cell responses and inducing B cell antibody response. IL21 also promotes the development of Th17 and Tfh cells, modulates the cytotoxic activity and survival of NK and CD8+ T cells, and suppresses the maturation of dendritic cells. It is also implicated in the development of autoimmune disease and has antitumor activity. |
| Host | Mouse |
| Immunogen | Ovalbumin-conjugated synthetic peptide- LLQKAISRLA |
| Positive Control | Western Blot recombinant IL21; IHC - Formalin-fixed, paraffin-embedded fish head kidney and spleen |
| Subclass | IgG |
| Myeloma Used | P3X63Ag8.653 |
| Strain | Balb/c |
| Notes |
Recommended Usage Conditions: ELISA - neat Western blot - neat IHC - 1/3 (antigen retrieval: microwave 20 min @ 800W in 10 mM citrate buffer, pH 6.0) |
| Research Area | Aquaculture, Cancer, Immunology |
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