Cancer Research Technology
Log in Register
Menu

Anti-IL21 [V28P5G1*C4]

Invented by Ayham Alnabulsi at Vertebrate Antibodies Limited

Info

Catalogue Number 153375
Applications ELISA IHC WB
Antigen/Gene or Protein Targets Interleukin 21 (IL21)
Synonyms IL 21 antibody, Interleukin 21 antibody, Interleukin21 antibody
Reactivity Salmon and Rainbow Trout
Relevance IL21 is a member of the type I cytokine family, which includes IL2 and IL15. IL21 signals through the common gamma-chain and a unique IL21 receptor. The IL21 receptor is expressed in cells lymphoid-lineage and regulates the proliferation and differentiation of T and B lymphocytes. Studies suggest that IL21 is a key component of CD4 T cell help that is required for maintaining the CD8+ T cell responses and inducing B cell antibody response. IL21 also promotes the development of Th17 and Tfh cells, modulates the cytotoxic activity and survival of NK and CD8+ T cells, and suppresses the maturation of dendritic cells. It is also implicated in the development of autoimmune disease and has antitumor activity.
Host Mouse
Immunogen Ovalbumin-conjugated synthetic peptide- LLQKAISRLA
Positive Control Western Blot recombinant IL21; IHC - Formalin-fixed, paraffin-embedded fish head kidney and spleen
Subclass IgG
Myeloma Used P3X63Ag8.653
Strain Balb/c
Notes Recommended Usage Conditions:
ELISA - neat
Western blot - neat
IHC - 1/3 (antigen retrieval: microwave 20 min @ 800W in 10 mM citrate buffer, pH 6.0)
Research Area Aquaculture, Cancer, Immunology

References

There are 0 reference entries for this reagent.

References: 0 entry

There is no reference for this reagent yet, feel free to use the button below to suggest one.

Add a reference

References: 0 entry

There is no reference for this reagent yet, feel free to use the button below to suggest one.

Add a reference