![Western blot data shows Anti-IL21 [V28P5G1*C4] specifically recognizes recombinant IL21 (expected size 20 KDa)](https://cancertools.org/wp-content/uploads/531e3dec-77de-4cae-b5fa-21b3e21f3224.png "531e3dec-77de-4cae-b5fa-21b3e21f3224.png")
Cat. #153375
Anti-IL21 [V28P5G1*C4]
Cat. #: 153375
Sub-type: Primary antibody
Unit size: 100 ug
Availability: 10-12 weeks
Target: Interleukin 21 (IL21)
Class: Monoclonal
Application: ELISA ; IHC ; WB
Reactivity: Salmon ; Rainbow Trout
Host: Mouse
£300.00
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Inventor: Ayham Alnabulsi
Institute: Vertebrate Antibodies Limited
Tool Details
*FOR RESEARCH USE ONLY
- Name: Anti-IL21 [V28P5G1*C4]
- Alternate name: IL 21 antibody, Interleukin 21 antibody, Interleukin21 antibody
- Clone: V28P5G1*C4
- Tool sub type: Primary antibody
- Class: Monoclonal
- Conjugation: Unconjugated
- Strain: Balb/c
- Reactivity: Salmon ; Rainbow Trout
- Host: Mouse
- Application: ELISA ; IHC ; WB
- Description: IL21 is a member of the type I cytokine family, which includes IL2 and IL15. IL21 signals through the common gamma-chain and a unique IL21 receptor. The IL21 receptor is expressed in cells lymphoid-lineage and regulates the proliferation and differentiation of T and B lymphocytes. Studies suggest that IL21 is a key component of CD4 T cell help that is required for maintaining the CD8+ T cell responses and inducing B cell antibody response. IL21 also promotes the development of Th17 and Tfh cells, modulates the cytotoxic activity and survival of NK and CD8+ T cells, and suppresses the maturation of dendritic cells. It is also implicated in the development of autoimmune disease and has antitumor activity.
- Immunogen: Ovalbumin-conjugated synthetic peptide- LLQKAISRLA
- Isotype: IgG
- Myeloma used: P3X63Ag8.653
- Recommended controls: Western Blot recombinant IL21; IHC - Formalin-fixed, paraffin-embedded fish head kidney and spleen
Target Details
- Target: Interleukin 21 (IL21)
- Tissue cell line specificity: Western Blot recombinant IL21; IHC - Formalin-fixed, paraffin-embedded fish head kidney and spleen
- Target background: IL21 is a member of the type I cytokine family, which includes IL2 and IL15. IL21 signals through the common gamma-chain and a unique IL21 receptor. The IL21 receptor is expressed in cells lymphoid-lineage and regulates the proliferation and differentiation of T and B lymphocytes. Studies suggest that IL21 is a key component of CD4 T cell help that is required for maintaining the CD8+ T cell responses and inducing B cell antibody response. IL21 also promotes the development of Th17 and Tfh cells, modulates the cytotoxic activity and survival of NK and CD8+ T cells, and suppresses the maturation of dendritic cells. It is also implicated in the development of autoimmune disease and has antitumor activity.
Applications
- Application: ELISA ; IHC ; WB
Handling
- Format: Liquid
- Concentration: 0.9-1.1 mg/ml
- Unit size: 100 ug
- Storage buffer: PBS with 0.02% azide
- Storage conditions: -15° C to -25° C
- Shipping conditions: Shipping at 4° C
